Results 71 to 80 of about 858,060 (289)

Recombining your way out of trouble: the genetic architecture of hybrid fitness under environmental stress [PDF]

, 2020
Hybridization between species is a fundamental evolutionary force that can both promote and delay adaptation. There is a deficit in our understanding of the genetic basis of hybrid fitness, especially in non-domesticated organisms.
Bendixsen, D., Greig, D., Janzen, T., Nolte, A., Stelkens, R., Zhang, Z.   +5 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation. [PDF]

, 2017
Sex chromosomes evolve once recombination is halted between a homologous pair of chromosomes. The dominant model of sex chromosome evolution posits that recombination is suppressed between emerging X and Y chromosomes in order to resolve sexual conflict.
A Kortrschal, A Lindholm, A Loytynoja, A McKenna, A Rimmer, AE Houde, AE Houde, AE Wright, AE Wright, AE Wright, AE Wright, AP Lisachov, AR Quinlan, B Charlesworth, B Langmead, B Sandkam, B Vicoso, B Vicoso, B Vicoso, B Vicoso, BA Fraser, BJA Pollux, C Dufresnes, D Bachtrog, D Bachtrog, D Bachtrog, D Kim, DJ Kemp, DR Kelley, E Axelsson, E Eden, E Eden, E Paradis, G Lunter, H Li, H Li, H Skaletsky, H Skaletsky, I Nanda, J Haldane, J Hough, J Kitano, JA Endler, JA Endler, JA Endler, JA Endler, JE Mank, JE Mank, JE Mank, JE Mank, JE Mank, JP Masly, JRW Russell, K Reichwald, KP Arunkumar, M Lohse, M Pertea, M Stock, M White, M Winge, MD Robinson, MD Robinson, N Tripathi, P Flicek, PW Harrison, Q Zhou, R Bergero, R Chikhi, RA Fisher, RB Luo, RH Devlin, RP Meisel, RP Meisel, RW Meredith, S Anders, SF Altschul, SP Gordon, SP Gordon, T Jombart, T Kamiya, T Lenormand, W Traut, WR Rice, ZH Yang, ZY Liu   +84 more
core   +4 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration [PDF]

Nature Reviews Genetics, 2013
The human Y chromosome is intriguing not only because it harbours the master-switch gene that determines gender but also because of its unusual evolutionary history. The Y chromosome evolved from an autosome, and its evolution has been characterized by massive gene decay.
openaire   +2 more sources

The influence of relatives on the efficiency and error rate of familial searching [PDF]

, 2013
We investigate the consequences of adopting the criteria used by the state of California, as described by Myers et al. (2011), for conducting familial searches.
Murphy, Erin, Rohlfs, Rori V., Slatkin, Montgomery, Song, Yun S.   +3 more
core   +5 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The Neolithic transition in Europe: archaeological models and genetic evidence [PDF]

, 2003
The major pattern in the European gene pool is a southeast-northwest frequency gradient of classic genetic markers such as blood groups, which population geneticists initially attributed to the demographic impact of Neolithic farmers dispersing from the ...
Richards, Martin B.
core   +4 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Traces of Paleolithic expansion in the Nivkh gene pool based on data on autosomal SNP and Y chromosome polymorphism

Вавиловский журнал генетики и селекции
The Nivkhs are a small ethnic group indigenous of the Russian Far East, living in the Khabarovsk Territory and on Sakhalin Island, descending from the ancient inhabitants of these territories.
V. N. Kharkov, N. A. Kolesnikov, L. V. Valikhova, A. A. Zarubin, A. L. Sukhomyasova, I. Yu. Khitrinskaya, V. A. Stepanov   +6 more
doaj   +1 more source