Results 51 to 60 of about 22,741,603 (305)

An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility

The Journal of Reproduction and Development, 2019
About 10% of male infertile patients show abnormalities in spermatogenesis. The microdeletion of azoospermia factor a (AZFa) region of the Y chromosome is thought to be a cause of spermatogenic failure.
Takafumi MATSUMURA, Tsutomu ENDO, Ayako ISOTANI, Masaki OGAWA, Masahito IKAWA   +4 more
doaj   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Comparative Chromosome Maps of Neotropical Rodents Necromys lasiurus and Thaptomys nigrita (Cricetidae) Established by ZOO-FISH [PDF]

, 2011
This work presents chromosome homology maps between Mus musculus (MMU) and 2 South American rodent species from the Cricetidae group: Necromys lasiurus (NLA, 2n = 34) and Thaptomys nigrita (TNI, 2n = 52), established by ZOO-FISH using mouse chromosome ...
Müller, Stefan, I.J. Sbalqueiro, Artoni, R. F., Hass, I., S. Müller, R.F. Artoni, Sbalqueiro, I. J., I. Hass   +7 more
core   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Population growth of human Y chromosomes: a study of Y chromosome microsatellites [PDF]

Molecular Biology and Evolution, 1999
We use variation at a set of eight human Y chromosome microsatellite loci to investigate the demographic history of the Y chromosome. Instead of assuming a population of constant size, as in most of the previous work on the Y chromosome, we consider a model which permits a period of recent population growth.
J K, Pritchard, M T, Seielstad, A, Perez-Lezaun, M W, Feldman   +3 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The association between male infertility and sperm disomy: Evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairs [PDF]

, 2004
BACKGROUND: The association between infertility and sperm disomy is well documented. Results vary but most report that men with severely compromised semen parameters have a significantly elevated proportion of disomic sperm.
Xiao P Zhai, Homa, ST, Christopikou Dimitra, Christopikou, D, Homa, Sheryl T., Zhai, Xiao-Ping, Tempest, Helen G., Dalakiouridou, Maria, Griffin Darren K, David Wright, Wright, David B., Darren K Griffin, Sheryl T Homa, Wright, D, Maria Dalakiouridou, Griffin, DK, Dimitra Christopikou, Wright David, Homa Sheryl T, Dalakiouridou Maria, Tempest Helen G, Tempest, HG, Helen G Tempest, Dalakiouridou, M, Zhai Xiao P, Zhai, XP, Christopikou, Dimitra, Griffin, Darren K.   +27 more
core   +1 more source

Assembly of the threespine stickleback Y chromosome reveals convergent signatures of sex chromosome evolution [PDF]

, 2020
Background: Heteromorphic sex chromosomes have evolved repeatedly across diverse species. Suppression of recombination between X and Y chromosomes leads to degeneration of the Y chromosome.
Cech, Jennifer N, Schmutz, Jeremy, Urton, James R, Naftaly, Alice FS, Peichel, Catherine L., Kingsley, David M, McCann, Shaugnessy R, Myers, Richard M, Grimwood, Jane, Ross, Joseph A, White, Michael A, Kingsley, David M., McCann, Shaugnessy R., Cech, Jennifer N., Ross, Joseph A., Urton, James R., White, Michael A., Naftaly, Alice F. S., Myers, Richard M.   +18 more
core   +2 more sources

Populations of Transcarpathia and Bukovina on the genetic landscape of surrounding regions

Regulatory Mechanisms in Biosystems, 2015
The territory of present-day Ukraine is subdivided into some regions with specific demographic and politic history. Nevertheless, the corresponding subdivision in genetic structure is not revealed in previous investigations: populations of Ukrainians ...
O. M. Utevska, M. I. Chukhraeva, A. T. Agdzhoyan, L. A. Atramentova, E. V. Balanovska, O. P. Balanovsky   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source