Results 231 to 240 of about 102,889 (306)

VGLL4-driven TEAD4 multimerization orchestrates DNA binding and YAP recruitment. [PDF]

Nat Commun
Ren Z, Zhao Y, Yu W, Zhang X, Song X, Bao Y, Hu M, Chen L, Yang H, Cheng B, Liu C, Jin Y, Zhang L, Sun B.   +13 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Aberrant activation of epigenetic BRD9-DGAT1 axis promotes lipid droplets deposition and ferroptosis resistance in YAP-high prostate cancer. [PDF]

Cell Death Dis
Zhu X, Wen Z, Wu J, Chen S, Xu R, Wang B, Zhu Y, Chen Y.   +7 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Lysophosphatidic acid mediates skeletal muscle fibrosis in denervation via activation of YAP/TAZ. [PDF]

JCI Insight
Cruz-Soca M, Córdova-Casanova A, Faundez-Contreras J, Martínez NW, Vaccaro-Rivera F, Bazaes-Astorga S, Gutiérrez-Rojas C, Gallardo FS, Rebolledo DL, Court FA, Chun J, Vio CP, Matus S, Casar JC, Brandan E.   +14 more
europepmc   +1 more source

Zinc Finger E‐Box Binding Homeobox 1 Mediates Alcohol‐Induced Liver Disease

iNew Medicine, EarlyView.
Alcohol intake leads to the upregulation of ZEB1, which activates the YAP‐IL‐1β/MCP‐1 pathway, resulting in the activation of liver inflammation and the induction of hepatocyte apoptosis. ABSTRACT Hepatitis resulting from alcoholic liver disease (ALD) is an important risk factor for liver cancer. It is essential to understand the role of ALD to prevent
Boyu Zhang, Chunyang Zhang, Xiao Cui, Tao Xu, Xiangpeng Hu, Jiong Gu   +5 more
wiley   +1 more source

Subclonal β-catenin/YAP signaling heterogeneity accelerates ovarian cancer metastasis through a senescence-associated secretory phenotype. [PDF]

Cell Death Dis
To SKY, Yang Y, Shi Z, Fung KSW, Lai SL, Li JJX, Ip PPC, Wong AST.   +7 more
europepmc   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Ccn2a acts downstream of cx43 to influence joint formation during zebrafish fin regeneration

Biology Open
Victoria Hyland, M. Kathryn Iovine
doaj   +1 more source

Retraction: SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source