Results 241 to 250 of about 283,339 (312)

Teknik dua paras terimbuh untuk kawalan optimum penyesuaian keadaan pegun proses tunggal [PDF]

, 2007
Andrew Yap Kian Chung,, Marzuki Mustafa,
core  

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Ccn2a acts downstream of cx43 to influence joint formation during zebrafish fin regeneration

Biology Open
Victoria Hyland, M. Kathryn Iovine
doaj   +1 more source

PI3K regulates TAZ/YAP and mTORC1 axes that can be synergistically targeted. [PDF]

JCI Insight
Garcia KC, Khan AA, Ghosh K, Sinha S, Scalora N, DeWane G, Fullenkamp C, Merritt N, Drebot Y, Yu SY, Leidinger M, Henry MD, Breheny PJ, Chimenti MS, Tanas MR.   +14 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

[Quercetin inhibits proliferation and migration and promotes apoptosis of gastric cancer cells by promoting phosphorylation-mediated YAP inactivation]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Wang Y, Wang W, Cheng S, Feng Y, Zhang Z, Shi Q, Li Y, Hu Q, Wu M.   +8 more
europepmc   +1 more source

The HIPPO pathway in gynecological malignancies

, 2020
Dong, J., He, J., Meyer, T., Wang, D., Xu, T.   +4 more
core  

Zinc Finger E‐Box Binding Homeobox 1 Mediates Alcohol‐Induced Liver Disease

iNew Medicine, EarlyView.
Alcohol intake leads to the upregulation of ZEB1, which activates the YAP‐IL‐1β/MCP‐1 pathway, resulting in the activation of liver inflammation and the induction of hepatocyte apoptosis. ABSTRACT Hepatitis resulting from alcoholic liver disease (ALD) is an important risk factor for liver cancer. It is essential to understand the role of ALD to prevent
Boyu Zhang, Chunyang Zhang, Xiao Cui, Tao Xu, Xiangpeng Hu, Jiong Gu   +5 more
wiley   +1 more source

Transient proliferation by reversible YAP and mitogen control of the cyclin D1/p27 ratio. [PDF]

Commun Biol
Ferrick KR, Upadhya SW, Fan Y, Ratnayeke N, Teruel MN, Meyer T.   +5 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source