Results 21 to 30 of about 62,440 (265)

Yap signalling regulates ductular reactions in mice with CRISPR/Cas9-induced glycogen storage disease type Ia

Animal Cells and Systems, 2022
Glycogen storage disease type Ia (GSD-Ia) is caused by a deficiency in the glucose-6-phosphatase (G6Pase, G6pc) enzyme, which catalyses the final step of gluconeogenesis and glycogenolysis.
Yixia Xie, Baowei Hu, Yue Gao, Yaxin Tang, Guohe Chen, Jiayuan Shen, Zhikai Jiang, He Jiang, Jiwei Han, Junyan Yan, Lifang Jin   +10 more
doaj   +1 more source

Narciclasine is a novel YAP inhibitor that disturbs interaction between YAP and TEAD4

BBA Advances, 2021
Yes-associated protein (YAP) is involved in development, cell growth, cell size, and homeostasis and plays a key role in the progression of various cancers. Among them, constitutive activation of YAP can often be observed in malignant mesothelioma, which arises in the pleura, peritoneum, and pericardium because of inactivation of the Hippo pathway.
Rie Kawamoto, Naoko Nakano, Haruka Ishikawa, Etsu Tashiro, Waka Nagano, Keigo Sano, Miki Irie, Mariko Ikuta, Fukuko Kishi, Takahisa Nakane, Mikihiko Naito, Susumu Itoh   +11 more
openaire   +3 more sources

Does Plant Size Influence Leaf Elements in an Arborescent Cycad?

Biology, 2018
Plant size influences the leaf nutrient relations of many species, but no cycad species has been studied in this regard. We used the arborescent Cycas micronesica K.D.
Thomas E. Marler, Murukesan V. Krishnapillai   +1 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Doğu Anadolu Bölgesinde Güvenilir Yağışın Belirlenmesi

Journal of Agricultural Sciences, 1997
Bu çal ışmada Doğu Anadolu Bölgesinde Ağrı , Bingöl, Elazığ , Erzincan, Erzurum, Iğd ı r, Kars, Malatya, Muş ve Tunceli illeri ile bu illere bağl ı 106 meteoroloji istasyonundan elde edilen verilere göre, güvenilir ya ğış değerlerinin elde edilmesine ...
Türker Türker, M.ali Tokgöz
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Ankara Murted Sulamasında Su Kullanım ve Dağıtım Etkinliğinin Belirlenmesi

Journal of Agricultural Sciences, 1997
Bu çal ışmada, Devlet Su I şleri taraf ı ndan 1971 y ı l ı nda işletmeye aç ı lan Mürted sulama projesi ele al ı nmış ve ovan ı n sulamas ı için yapı lan tesislerden optimum biçimde yararlanmaya ili şkin seçeneklerin araşt ı rı lmas ı planlanmıştı r. Bu
Nurinisa Ağlamış, M.ali Tokgoz
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Eskişehir Sulaması Sağ Sahil Sulama Alanında Sistem Performansının Değerlendirilmesi

Journal of Agricultural Sciences, 1998
Bu çal ışma Eskişehir Sulamas ı n ı n 1994 y ı l ı na iliş kin sulama sistem performans ı n ı n değ erlendirilmesi amac ı yla yap ı lm ışt ı r. Eskişehir Sağ Sahil Sulamas ı araşt ı rma alan ı olarak seçilmi ştir.
Boğaçhan Benli, Mevlüt Beyrıbey
doaj   +1 more source