Results 31 to 40 of about 283,339 (312)

Akdeniz Bölgesinde Güvenilir Ya ğışın Belirlenmesi

Journal of Agricultural Sciences, 1998
Bu çal ışmada Akdeniz Bölgesinde bulunan Adana, Antalya, Isparta, Mersin, iç Anadolu Bölgesinde bulunan Kayseri, Nevşehir, Niğde ve Ege Bölgesinde bulunan Mu ğ la ili ile bu iftara bağ l ı meteoroloji istasyonlar ı ndan elde edilen verilere göre ...
Emel Emre, M.fatih Selenay
doaj   +1 more source

Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins [PDF]

, 2015
SummaryAs the key effector in the Hippo pathway, YAP was identified as an oncoprotein whose expression is elevated in various human cancers. However, the development of potentially therapeutic compounds targeting YAP has been slow and limited.
Wang, Wenqi, Li, Nan, Li, Xu, Tran, My Kim, Han, Xin, Chen, Junjie   +5 more
core   +4 more sources

Yap signalling regulates ductular reactions in mice with CRISPR/Cas9-induced glycogen storage disease type Ia

Animal Cells and Systems, 2022
Glycogen storage disease type Ia (GSD-Ia) is caused by a deficiency in the glucose-6-phosphatase (G6Pase, G6pc) enzyme, which catalyses the final step of gluconeogenesis and glycogenolysis.
Yixia Xie, Baowei Hu, Yue Gao, Yaxin Tang, Guohe Chen, Jiayuan Shen, Zhikai Jiang, He Jiang, Jiwei Han, Junyan Yan, Lifang Jin   +10 more
doaj   +1 more source

The Evolutionary History of YAP and the Hippo/YAP Pathway

Molecular Biology and Evolution, 2011
The Hippo/YAP pathway plays an important role in animal organ size control, which it exerts by regulating tissue proliferation and apoptosis rates as a response to developmental cues, cell contact, and density. With the ever increasing advance in genome sequencing and analysis tools, our understanding of the animal world and its evolution has greatly ...
Dror, Hilman, Uri, Gat
openaire   +2 more sources

Does Plant Size Influence Leaf Elements in an Arborescent Cycad?

Biology, 2018
Plant size influences the leaf nutrient relations of many species, but no cycad species has been studied in this regard. We used the arborescent Cycas micronesica K.D.
Thomas E. Marler, Murukesan V. Krishnapillai   +1 more
doaj   +1 more source

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. [PDF]

, 2015
The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes.
A Kapoor, A Krapp, A Rada-Iglesias, A Sawada, A-C Binot, AF Hezel, AJ Saldanha, B Zhao, B Zhao, C Cortijo, C Haumaitre, C Trapnell, CHH Cho, CY McLean, DA Stoffers, DW Huang, E Kroon, E Rodríguez-Seguel, EF Chiang, F Argenton, F Esni, F Supek, FC Lynn, FC Pan, H Fang, H Fang, H Lango Allen, I Morán, I Rooman, J Bessa, J van Arensbergen, JM Oliver-Krasinski, K Kawakami, K Piper, K Piper, K Skouloudaki, KJ Gaulton, KM Petzold, KS Zaret, L Elghazi, L Pasquali, M Borowiak, M Carrasco, M Gannon, MA Maestro, MC Whitlock, MF Offield, MJL de Hoon, MN Weedon, MP Creyghton, N Bardeesy, N Gao, NM George, P Jacquemin, PA Seymour, R O’Rahilly, R Xie, RE Jennings, RF Luco, S Gupta, S Heinz, S Xuan, T Derrien, T Jowett, W Zhang, WA Whyte, Y Fujitani, Y Liu-Chittenden   +67 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Doğu Anadolu Bölgesinde Güvenilir Yağışın Belirlenmesi

Journal of Agricultural Sciences, 1997
Bu çal ışmada Doğu Anadolu Bölgesinde Ağrı , Bingöl, Elazığ , Erzincan, Erzurum, Iğd ı r, Kars, Malatya, Muş ve Tunceli illeri ile bu illere bağl ı 106 meteoroloji istasyonundan elde edilen verilere göre, güvenilir ya ğış değerlerinin elde edilmesine ...
Türker Türker, M.ali Tokgöz
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer [PDF]

, 2016
Male breast cancer (MBC) is a rare disease and its biology is poorly understood. Deregulated Hippo pathway promotes oncogenic functions in female breast cancer.
Bardeesy, Bartsch, Bartsch, Basso, Bhargava, Brummelkamp, Cancer Genome Atlas Network, Chen, Cordenonsi, Costa, Daidone, De Maria, Del Sal, Di Fiore, Fjällskog, Fuchs, Guan, Gumbiner, Guénel, Hedenfalk, Hedenfalk, Ito, Jiang, Kuperwasser, Lakshmanaswamy, Lalloo, Lei, Lim, Little, Litwiniuk, Maugeri-Saccà, Maugeri-Saccà, Maugeri-Saccà, Palacios, Pan, Pan, Pan, Pan, Patrizii, Piccolo, Rosenberg, Rosenberg, Semenza, Semenza, Sergi, Speirs, Thomas, Thyss, van Diest, Winer, Wrana, Xu, Yurchenco   +52 more
core   +3 more sources