Results 41 to 50 of about 283,339 (312)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Ankara Murted Sulamasında Su Kullanım ve Dağıtım Etkinliğinin Belirlenmesi

Journal of Agricultural Sciences, 1997
Bu çal ışmada, Devlet Su I şleri taraf ı ndan 1971 y ı l ı nda işletmeye aç ı lan Mürted sulama projesi ele al ı nmış ve ovan ı n sulamas ı için yapı lan tesislerden optimum biçimde yararlanmaya ili şkin seçeneklerin araşt ı rı lmas ı planlanmıştı r. Bu
Nurinisa Ağlamış, M.ali Tokgoz
doaj   +1 more source

Hypoxic conditions differentially regulate TAZ and YAP in cancer cells [PDF]

, 2014
The Hippo-YAP pathway is altered and implicated as an oncogenic signaling pathway in many human cancers. Hypoxia is an important microenvironmental factor that promotes tumorigenesis.
Cai, Qingchun, Xu, Yan, Yan, Libo
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Eskişehir Sulaması Sağ Sahil Sulama Alanında Sistem Performansının Değerlendirilmesi

Journal of Agricultural Sciences, 1998
Bu çal ışma Eskişehir Sulamas ı n ı n 1994 y ı l ı na iliş kin sulama sistem performans ı n ı n değ erlendirilmesi amac ı yla yap ı lm ışt ı r. Eskişehir Sağ Sahil Sulamas ı araşt ı rma alan ı olarak seçilmi ştir.
Boğaçhan Benli, Mevlüt Beyrıbey
doaj   +1 more source

Hippo pathway effectors control cardiac progenitor cell fate by acting as dynamic sensors of substrate mechanics and nanostructure [PDF]

, 2014
Stem cell responsiveness to extracellular matrix (ECM) composition and mechanical cues has been the subject of a number of investigations so far, yet the molecular mechanisms underlying stem cell mechano-biology still need full clarification.
Aoyagi, T, Di Nardo, P, Ebara, M, Escobedo-Lucea, C, Forte, G, Franzese, O, Goumans, MJ, Mosqueira, D, Nakanishi, J, Pagliari, S, Pinto-Do-O, P, Romanazzo, S, Taniguchi, A, Traversa, E, Uto, K   +14 more
core   +1 more source

Enigma proteins regulate YAP mechanotransduction [PDF]

Journal of Cell Science, 2018
ABSTRACT Human cells can sense mechanical stress acting upon integrin adhesions and respond by sending the YAP (also known as YAP1) and TAZ (also known as WWTR1) transcriptional co-activators to the nucleus to drive TEAD-dependent transcription of target genes. How integrin signaling activates YAP remains unclear.
Ahmed Elbediwy, Hannah Vanyai, Maria-del-Carmen Diaz-de-la-Loza, David Frith, Ambrosius P. Snijders, Barry J. Thompson   +5 more
openaire   +3 more sources

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

Sulama Şebekelerinin izleme ve Değerlendirilmesinde Ortalama ve Yıllık Veri Kullanımı

Journal of Agricultural Sciences, 1997
Sulama şebekelerinde su yönetimi çal ışmalar ı gene! sulama planlamas ı , planl ı su dağıt ı mı ve sulama sonuçlar ı n ı n değerlendirilmesi aşamalar ı n ı içermektedir. Ülkemizde sulama sonuçlar ı değerlendirme çal ışmalar ı nda uzun y ı llar ortalamas
Mevlüt Beyribey, Kemal Sönmez, Belgin Çakmak, Mehmet Oğuz   +3 more
doaj  

Konya Ovası Sulamalarında Tabansuyu ve Tuzluluk Sorunları

Journal of Agricultural Sciences, 2001
Çiftçilerin bilinçsiz sulama uygulamalar ı ve a şı rı su kullan ı m ı , erozyon, göllenme, tuzluluk, sodyumluluk gibi çevresel problemlere yol açmaktad ı r.
Belgin Çakmak, Berna Kendırlı
doaj   +1 more source