Results 41 to 50 of about 102,889 (306)

Yap signalling regulates ductular reactions in mice with CRISPR/Cas9-induced glycogen storage disease type Ia

Animal Cells and Systems, 2022
Glycogen storage disease type Ia (GSD-Ia) is caused by a deficiency in the glucose-6-phosphatase (G6Pase, G6pc) enzyme, which catalyses the final step of gluconeogenesis and glycogenolysis.
Yixia Xie, Baowei Hu, Yue Gao, Yaxin Tang, Guohe Chen, Jiayuan Shen, Zhikai Jiang, He Jiang, Jiwei Han, Junyan Yan, Lifang Jin   +10 more
doaj   +1 more source

Does Plant Size Influence Leaf Elements in an Arborescent Cycad?

Biology, 2018
Plant size influences the leaf nutrient relations of many species, but no cycad species has been studied in this regard. We used the arborescent Cycas micronesica K.D.
Thomas E. Marler, Murukesan V. Krishnapillai   +1 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Substrate Topography Regulates Differentiation of Annulus Fibrosus-Derived Stem Cells via CAV1-YAP-Mediated Mechanotransduction

, 2020
Regeneration of annulus fibrosus (AF) through tissue engineering techniques shows promise as a treatment for patients with degenerative disc disease (DDD). Yet, it remains challenging because of the intrinsic heterogeneity of AF tissue and shortage of in-
Zhangqin Yuan (106370), Weidong Zhang, Pinghui Zhou (8630967), Bin Li (39349), Qiang Yang, Huilin Yang (303871), Jiaying Li, Huan Wang (109286), Qiang Yang (135832), Caihong Zhu, Huan Wang, Huilin Yang, Bin Li, Genglei Chu, Zhangqin Yuan, Genglei Chu (8630964), Jiaying Li (3250335), Feng Zhou, Weidong Zhang (68880), Caihong Zhu (166706), Feng Zhou (76988), Pinghui Zhou   +21 more
core   +1 more source

Doğu Anadolu Bölgesinde Güvenilir Yağışın Belirlenmesi

Journal of Agricultural Sciences, 1997
Bu çal ışmada Doğu Anadolu Bölgesinde Ağrı , Bingöl, Elazığ , Erzincan, Erzurum, Iğd ı r, Kars, Malatya, Muş ve Tunceli illeri ile bu illere bağl ı 106 meteoroloji istasyonundan elde edilen verilere göre, güvenilir ya ğış değerlerinin elde edilmesine ...
Türker Türker, M.ali Tokgöz
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Yap

yap"To Yap". To retort angrily.

core   +6 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Ankara Murted Sulamasında Su Kullanım ve Dağıtım Etkinliğinin Belirlenmesi

Journal of Agricultural Sciences, 1997
Bu çal ışmada, Devlet Su I şleri taraf ı ndan 1971 y ı l ı nda işletmeye aç ı lan Mürted sulama projesi ele al ı nmış ve ovan ı n sulamas ı için yapı lan tesislerden optimum biçimde yararlanmaya ili şkin seçeneklerin araşt ı rı lmas ı planlanmıştı r. Bu
Nurinisa Ağlamış, M.ali Tokgoz
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source