Results 221 to 230 of about 36,484 (234)

Domain-specific mechanisms of YAP1 variants in ocular coloboma revealed by in-vitro and organoid studies

Silvano S, Rick-Lenze A, Bagnall J, Saravanakumar M, Yang X, Lea R, Birchall L, Jones JR, Davis JM, Miller A, Jennings RE, Stolerman E, Ellingford JM, Lovell SC, Manson F, Arno G, Sergouniotis PI, Manning CS.   +17 more
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Rejuvenation of tendon stem/progenitor cells for functional tendon regeneration through platelet-derived exosomes loaded with recombinant Yap1.

Acta Biomaterialia, 2023
The regenerative capabilities including self-renewal, migration and differentiation potentials shift from the embryonic phase to the mature period of endogenous tendon stem/progenitor cells (TSPCs) characterize restricted functions and disabilities ...
Jinwei Lu, Xiaohui Yang, Chaofan He, Yazhou Chen, Congsun Li, Sihao Li, Yuewei Chen, Yifan Wu, Zhi-Xiong Xiang, Jiawei Kang, Guang-yao Jiang, Cong Wang, Mohamed Diaty Diarra, Rongxin He, G. Feng, Ruijian Yan   +15 more
semanticscholar   +1 more source

Extracellular vesicles from bone marrow mesenchymal stem cells alleviate osteoporosis in mice through USP7-mediated YAP1 protein stability and the Wnt/β-catenin pathway.

Biochemical Pharmacology, 2023
Mesenchymal stem cells (MSCs) and their derived extracellular vesicles (EVs) have emerged as promising tools for promoting bone regeneration This study investigates the functions of EVs derived from bone marrow-derived MSCs (BMSCs) in osteoporosis (OP ...
Xuepeng Wang, Chunchun Zou, Changju Hou, Z. Bian, Wu Jiang, Maoqiang Li, Liulong Zhu   +6 more
semanticscholar   +1 more source

The role of Hippo/YAP1 in cancer-associated fibroblasts: Literature review and future perspectives

Cancer Letters
Cancer-associated fibroblasts (CAFs) are activated fibroblasts that play a role in numerous malignant phenotypes, including hyperproliferation, invasion, and metastasis.
Dipti Athavale, Curt Balch, Y. Zhang, Xiaodan Yao, Shumei Song   +4 more
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Targeting YAP1 ameliorates progesterone resistance in endometriosis.

Human Reproduction, 2023
STUDY QUESTION Does YAP1 inhibition alleviate progesterone resistance in endometriosis? SUMMARY ANSWER YAP1 inhibition reduces progesterone resistance in vitro and in vivo.
Shih-Chieh Lin, Wan-Ning Li, Shin-Chih Lin, Haun-Tzu Hou, Ya-Chuan Tsai, Tin-Chien Lin, Meng-Hsing Wu, S. Tsai   +7 more
semanticscholar   +1 more source

Lycium barbarum L. Balanced intestinal flora with YAP1/FXR activation in drug-induced liver injury.

International Immunopharmacology
Drug-induced liver injury (DILI) is a common and severe adverse drug reaction that can result in acute liver failure. Previously, we have shown that Lycium barbarum L.
Junlan Lu, Yuting Gao, Yi Gong, Yuan Yue, Yanguang Yang, Yajun Xiong, Yuman Zhang, Yan Xiao, Haodong Wang, Haibo Fan, Xinli Shi   +10 more
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YAP1 suppression inhibits autophagy and improves the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma.

Experimental Cell Research, 2023
Anti-PD-1 immunotherapy is a promising treatment for hepatocellular carcinoma (HCC), but some patients with HCC do not experience clinical benefits. Autophagy promotes tumor progression and participates in drug resistance.
Yuting Gao, Qing Peng, Shenghao Li, Kangning Zheng, Yi Gong, Yuehua Xue, Yiwei Liu, Junlan Lu, Yuman Zhang, Xinli Shi   +9 more
semanticscholar   +1 more source

Si-Ni-San reduces lipid droplet deposition associated with decreased YAP1 in metabolic dysfunction-associated fatty liver disease.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide. However, its complex pathogenesis and lack of effective drugs for treating it present significant challenges ...
Kangning Zheng, Wenhan Zhou, Jingmin Ji, Yuehua Xue, Yiwei Liu, Caige Li, Zhiqin Zhang, Junlan Lu, Xinli Shi, Yongmin Li   +9 more
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