Results 211 to 220 of about 32,177 (245)

Hepatitis C Virus NS5A Inhibits YAP1-HSC70 Interaction, Thereby Preventing YAP1 Degradation Via Chaperone-Mediated Autophagy

Hepatitis C Virus NS5A Inhibits YAP1-HSC70 Interaction, Thereby Preventing YAP1 Degradation Via Chaperone-Mediated Autophagy
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All eyes on YAP1

Nature Reviews Cancer, 2014
Sarah E Seton-Rogers
exaly   +2 more sources

C11orf95-RELA, YAP1-MAMLD1, and YAP1-FAM118B Fusion Negative Anaplastic Ependymoma with Lipogenic Differentiation

Neurology India, 2023
Lipogenic differentiation in ependymoma is an infrequent occurrence with very few reported cases. The grading was done solely based on the histomorphology and molecular subtyping was not described in such ependymomas. New molecular classification divided ependymomas in nine different subgroups, of which supratentorial location
Shilpy, Jha, Prit Benny, Mulgulwar, Mehar Chand, Sharma, Suvendu, Purkait, Ashis, Pattnaik, Mukund Namdev, Sable   +5 more
openaire   +2 more sources

YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition

Gut, 2020
ObjectivePeritoneal carcinomatosis (PC; malignant ascites or implants) occurs in approximately 45% of advanced gastric adenocarcinoma (GAC) patients and associated with a poor survival. The molecular events leading to PC are unknown. The yes-associated protein 1 (YAP1) oncogene has emerged in many tumour types, but its clinical significance in PC is ...
Jaffer A Ajani, Yan Xu, Longfei Huo, Ruiping Wang, Yuan Li, Ying Wang, Melissa Pool Pizzi, Ailing Scott, Kazuto Harada, Lang Ma, Xiaodan Yao, Jiankang Jin, Wei Zhao, Xiaochuan Dong, Brian D Badgwell, Namita Shanbhag, Ghia Tatlonghari, Jeannelyn Santiano Estrella, Sinchita Roy-Chowdhuri, Makoto Kobayashi, Jody V Vykoukal, Samir M Hanash, George Adrian Calin, Guang Peng, Ju-Seog Lee, Randy L Johnson, Zhenning Wang, Linghua Wang, Shumei Song   +28 more
openaire   +2 more sources

All roads lead to YAP1

Nature Reviews Cancer, 2010
Gemma K Alderton
exaly   +2 more sources

Targeting YAP1 ameliorates progesterone resistance in endometriosis

Human Reproduction, 2023
Abstract STUDY QUESTION Does YAP1 inhibition alleviate progesterone resistance in endometriosis? SUMMARY ANSWER YAP1 inhibition reduces progesterone resistance in vitro and in vivo ...
Shih-Chieh Lin, Wan-Ning Li, Shin-Chih Lin, Haun-Tzu Hou, Ya-Chuan Tsai, Tin-Chien Lin, Meng-Hsing Wu, Shaw-Jenq Tsai   +7 more
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Loss of expression of YAP1 C-terminus as an ancillary marker for epithelioid hemangioendothelioma variant with YAP1-TFE3 fusion and other YAP1-related vascular neoplasms

Modern Pathology, 2021
Epithelioid hemangioendothelioma (EHE) with YAP1-TFE3 fusion is a recently characterized distinctive variant of EHE that accounts for a small subset (
William J. Anderson, Christopher D.M. Fletcher, Jason L. Hornick   +2 more
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Antisense Oligos May Hit “Undruggable” YAP1

Cancer Discovery, 2021
Abstract An antisense oligonucleotide that targets the Hippo pathway protein YAP1, long thought “undruggable,” has shown preclinical promise and is under evaluation in a phase I trial.
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Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers [PDF]

Nature Medicine, 2014
Oncogene–induced DNA damage elicits genomic instability in epithelial cancer cells, but apoptosis is blocked through inactivation of the tumor suppressor p53. In hematological cancers, the relevance of ongoing DNA damage and mechanisms by which apoptosis
Francesca Cottini, Martin Sattler, Martina Dori   +2 more
exaly   +4 more sources