Results 221 to 230 of about 23,828 (263)

Bemarituzumab Suppresses Choroidal Neovascularization in Mice by Downregulating Melanoma Cell Adhesion Molecule and Yes-Associated Protein 1. [PDF]

ACS Pharmacol Transl Sci
Ding L, Xie B, Lv J, Zhou Z, Zhou X, Wu K, Zhang Q, Lu F, Wang C, Qu J, Xiang L, Chen Q.   +11 more
europepmc   +1 more source

TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma. [PDF]

Oncogene
Vuong AT, Joshi AS, Roy A, Mathukumalli K, Ho PT, Bhat R, Tomaz da Silva M, Samanta T, Trivedi MV, Guo B, Kaipparettu BA, Kumar A.   +11 more
europepmc   +1 more source

Research on the regulation of osteogenic differentiation and mechanotransduction by porous bionic coatings on titanium alloy implant surfaces. [PDF]

RSC Adv
Zou Z, Jiang S, Chen W, Wang Y, Liang Q, Fang W, Zhan X, Gu R, Chen Q.   +8 more
europepmc   +1 more source

Enhancing gastric cancer immunotherapy: Insights from multi-omics analysis and innovations in photodynamic-chemotherapy nanoplatforms. [PDF]

Cell Rep Med
Qiu QZ, Gao YX, Zhao YX, Fan DH, Yang XP, Lin TX, Jiang CY, Huang ZN, Zheng QL, Huang ZH, Li Y, Zheng CH, Li P, Xie JW, Wang JB, Nomura S, Chen Q, Chen QY, Huang CM.   +18 more
europepmc   +1 more source

Epigenetic remodeling in sarcoma promotes T-cell infiltration via modulation of the Hippo pathway. [PDF]

J Immunother Cancer
Cruz De Los Santos M, Chen Y, González De Zárate A, Sorteberg A, Zhao H, Vázquez-Cabrera G, Bigdeli N, Kolbeinsdottir S, Mannion A, Baldran-Groves L, Neo SY, Wickström SL, Melief J, Holmgren L, Herold N, Haglund de Flon F, Lundqvist A.   +16 more
europepmc   +1 more source

OSBPL3 drives colorectal cancer progression via Hippo-YAP signaling and modulates MEK inhibitor sensitivity. [PDF]

Commun Biol
Zhong Y, Zheng C, Wang Z, Zhang W, Wu H, Luo J, Zhang H, Wang C, Zhang C, Hu H, Yuan Z, Wang M, Zhang Q, Wang G.   +13 more
europepmc   +1 more source

Expression of YAP1 in aggressive thyroid cancer [PDF]

Endocrine, 2017
The Hippo signal transduction pathway plays a crucial role in the control of cellular proliferation, so that its deregulation is believed to be involved in neoplastic transformation [1, 2]. A wide array of human cancers show a down-regulation of Hippo pathway, resulting in the activation of the co-transcription factors Yes-associated protein (YAP1) as ...
Celano, Marilena, Mignogna, Chiara, ROSIGNOLO, FRANCESCA, SPONZIELLO, Marialuisa, Iannone, Michelangelo, Lepore, Saverio Massimo, Lombardo, Giovanni Enrico, Maggisano, Valentina, VERRIENTI, Antonella, Bulotta, Stefania, DURANTE, COSIMO, Di Loreto, Carla, Damante, Giuseppe, Russo, Diego   +13 more
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YAP1::MAML2, YAP1::NUTM1, and RNF13::PAK2 rearrangements in trichoblastomas and adnexal tumors with panfollicular differentiation: expanding the spectrum of YAP1/PAK-fused skin adnexal tumors [PDF]

Virchows Archiv
In 2019, YAP1::MAML2 and YAP1::NUTM1 rearrangements were demonstrated in the majority of poromas and in porocarcinomas. Recently, our group demonstrated recurrent fusions of PAK (p21 (RAC1) activated kinase) 1/2/3 genes in a subset of poromas and porocarcinomas frequently harboring hair follicle and sebaceous differentiation.
Kervarrec, Thibault, Macagno, Nicolas, Houlier, Aurelie, Pissaloux, Daniel, Thamphya, Brice, Louveau, Baptiste, Mourah, Samia, Mancini, Maxence, Kazakov, Dmitry, Harnisch, Kim, Tirode, Franck, Cazzato, Gerardo, Sohier, Pierre, de la Fouchardière, Arnaud, Battistella, Maxime, Calonje, Eduardo   +15 more
openaire   +4 more sources

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YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition

Gut, 2020
Objective Peritoneal carcinomatosis (PC; malignant ascites or implants) occurs in approximately 45% of advanced gastric adenocarcinoma (GAC) patients and associated with a poor survival. The molecular events leading to PC are unknown.
Jaffer A Ajani, Yan Xu, Longfei Huo, Ruiping Wang, Yuan Li, Ying Wang, Melissa Pool Pizzi, Ailing Scott, Kazuto Harada, Lang Ma, Xiaodan Yao, Jiankang Jin, Wei Zhao, Xiaochuan Dong, Brian D Badgwell, Namita Shanbhag, Ghia Tatlonghari, Jeannelyn Santiano Estrella, Sinchita Roy-Chowdhuri, Makoto Kobayashi, Jody V Vykoukal, Samir M Hanash, George Adrian Calin, Guang Peng, Ju-Seog Lee, Randy L Johnson, Zhenning Wang, Linghua Wang, Shumei Song   +28 more
openaire   +2 more sources

Loss of expression of YAP1 C-terminus as an ancillary marker for epithelioid hemangioendothelioma variant with YAP1-TFE3 fusion and other YAP1-related vascular neoplasms

Modern Pathology, 2021
Epithelioid hemangioendothelioma (EHE) with YAP1-TFE3 fusion is a recently characterized distinctive variant of EHE that accounts for a small subset (
William J. Anderson, Christopher D.M. Fletcher, Jason L. Hornick   +2 more
openaire   +2 more sources