Results 221 to 230 of about 23,621 (250)

Antisense Oligos May Hit “Undruggable” YAP1

Cancer Discovery, 2021
Abstract An antisense oligonucleotide that targets the Hippo pathway protein YAP1, long thought “undruggable,” has shown preclinical promise and is under evaluation in a phase I trial.
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YAP1 Is a Crucial Nexus in the Tumor Microenvironment

Current Medical Science
Yes-associated protein-1 (YAP1) is an oncogenic effector of the Hippo signaling pathway, activated in several cancer types, and has been extensively studied in cancer progression and therapy. A large number of studies have established the importance of YAP1 in promoting cell-autonomous functions, including uncontrolled growth, sustained proliferative ...
Raghavan, Narasimhan, Anshula, Narayanasamy, Jaya, Padmanabhan, Srikumar, Chellappan, Durairaj, Mohan Kumar   +4 more
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YAP1::NR4A3 and YAP1::NCOA2 fusions in poroma: expanding the spectrum of molecular alterations in poroid tumors

Virchows Archiv
International ...
Secco, Léo-Paul, Libbrecht, Louis, Bonny, Michiel, Lepine, Charles, Švajdler, Marián, Tallet, Anne, Chantreau, Paul-Louis, Cormier, Benedicte, Cribier, Bernard, Siozopoulou, Vasiliki, Kervarrec, Thibault   +10 more
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A novel YAP1-MAML2 fusion in an adult supra-tentorial ependymoma, YAP1-fused

Brain Tumor Pathology, 2022
Tauziède-Espariat, Arnault, Siegfried, Aurore, Nicaise, Yvan, Figarella‑branger, Dominique, Appay, Romain, Senova, Suhan, Bochaton, Dorian, Hasty, Lauren, Martin, Anna, Chrétien, Fabrice, Métais, Alice, Varlet, Pascale, Uro-Coste, Emmanuelle   +12 more
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Yap1/Taz are essential for the liver development in zebrafish

Biochemical and Biophysical Research Communications, 2018
Hippo pathway regulates cell proliferation and differentiation. Yes-associated protein (Yap) and transcriptional coactivator with PDZ-binding motif (Taz) are effectors of Hippo pathway. The function of Yap/Taz in embryonic liver development has yet to be reported.
Xiaogui Yi, Jia Yu, Chao Ma, Li Li, Lingfei Luo, Hongtao Li, Hua Ruan, Honghui Huang   +7 more
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YAP1 and WWTR1 are required for murine pregnancy initiation

Reproduction
In brief The HIPPO signaling effectors YAP1 and WWTR1 are required for murine pregnancy initiation, and mutation of these factors compromises the decidualization response and overall pregnancy success.
Genna E Moldovan, Noura Massri, Erin L Vegter, Ivonne N Pauneto-Delgado, Gregory W Burns, Niraj Joshi, Bin Gu, Ripla Arora, Asgerally T Fazleabas   +8 more
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Nuclear condensates in YAP1-driven ependymoma

Nature Cell Biology, 2023
Mahsa Shahidi Dadras, Howard A. Fine
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Correction: YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition

Gut, 2021
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YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance

Developmental Biology, 2021
Frank Szulzewsky, Eric C Holland, Valeri Vasioukhin   +2 more
exaly  

Enhanced nuclear localization of YAP1‐2 contributes to EGF‐induced EMT in NSCLC

Journal of Cellular and Molecular Medicine, 2022
Xue Li, Chengshui Chen, Jin-San Zhang
exaly