Results 51 to 60 of about 87,830 (283)

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Supporting people with cognitive disabilities in decision making – processes and dilemmas [PDF]

, 2015
The exploratory study found that participants, including those with cognitive disability, mostly supported the broad concept of supported decision making.
Mary Whiteside, Christine Bigby, Jacinta Douglas   +2 more
core  

Median global number of foodborne illnesses, deaths, Years Lived with Disability (YLDs), Years of Life Lost (YLLs) and Disability Adjusted Life Years (DALYs), with 95% uncertainty intervals, 2010.

, 2016
Median global number of foodborne illnesses, deaths, Years Lived with Disability (YLDs), Years of Life Lost (YLLs) and Disability Adjusted Life Years (DALYs), with 95% uncertainty intervals, 2010.
Martyn D. Kirk (833166), David C. Bellinger (69691), Nilanthi R. de Silva (833172), Niko Speybroeck (40990), Frederick J. Angulo (833168), Arie H. Havelaar (170779), Colin Mathers (264723), Herman J. Gibb (833169), Brecht Devleesschauwer (505283), Nicolas Praet (175170), Tine Hald (833170), Amy Cawthorne (833174), Neyla Gargouri (833173), Claudia Stein (170785), Paul R. Torgerson (280377), Robin J. Lake (833171)   +15 more
core   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Total temporary and lifelong years lived with disability, years of life lost and disability-adjusted life-years per 1-year interval (2010–2012).

, 2014
Total temporary and lifelong years lived with disability, years of life lost and disability-adjusted life-years per 1-year interval (2010–2012).
Juanita A. Haagsma (237271), Suzanne Polinder (360134), Annemieke C. Scholten (649069), Martien J. M. Panneman (347330), Ed F. van Beeck (347331)   +4 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

The global burden of cardiovascular disease attributable to high alcohol use from 1990 to 2021: an analysis for the global burden of disease study 2021

Frontiers in Public Health
BackgroundCardiovascular diseases (CVDs) are the leading global disease burden, with alcohol consumption closely linked to their occurrence. This study analyzes data from the Global Burden of Disease Study 2021 (GBD 2021) to assess the distribution and ...
Chaofeng Niu, Juwei Dong, Peiyu Zhang, Qiwen Yang, Donghua Xue, Birong Liu, Di Xiao, Rui Zhuang, Meng Li, Lijing Zhang   +9 more
doaj   +1 more source

How Adults With an Intellectual Disability Experience Bereavement and Grief: A Qualitative Exploration

, 2014
This qualitative study explored the lived experiences of bereavement of 13 adults with an intellectual disability and found that their experiences could be situated within the concept of disenfranchised grief.
Quayle, Ethel; id_orcid, Neumann, Katja, McRitchie, Robyn, McKenzie, Karen, Quayle, Ethel, Harlin, Margaret   +5 more
core   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Listening and learning: adults with mild learning disabilities' lived experience of individual counselling [PDF]

, 2012
Learning disability services aspire to the social model of disability which acknowledges the expertise of service-users on all aspects of their lives. Counselling is now more widely accepted as a treatment approach for the emotional problems of people ...
Fitzgerald, Catherine M.
core