Results 51 to 60 of about 66,680,146 (171)

Measuring the population burden of injuries--implications for global and national estimates: a multi-centre prospective UK longitudinal study.

PLoS Medicine, 2011
BackgroundCurrent methods of measuring the population burden of injuries rely on many assumptions and limited data available to the global burden of diseases (GBD) studies.
Ronan A Lyons, Denise Kendrick, Elizabeth M Towner, Nicola Christie, Steven Macey, Carol Coupland, Belinda J Gabbe, UK Burden of Injuries Study Group   +7 more
doaj   +1 more source

Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment

MedComm, Volume 7, Issue 9, September 2026.
Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu, Yuan Zhang, Chen Shi, Yu Tao, Shaoxin Li, Yufang Sun, Fuhai Ji, Dongsheng Jiang, Terrance P. Snutch, Jin Tao   +9 more
wiley   +1 more source

Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats

Aging Cell, Volume 25, Issue 9, September 2026.
Aging impairs flexor tendon repair, with aged tendons showing reduced Col1a1 and Sparc expression and compromised mechanical properties. The transcription factor Creb3l1 binds both gene promoters and drives their expression; its overexpression restores Col1a1 and Sparc levels and improves the gliding function, healing strength, and elastic modulus of ...
Qian Qian Yang, Zhanghao Huang, Yan Xue, Jia Yu Shi, You Lang Zhou   +4 more
wiley   +1 more source

Global, regional, and national burden of fracture of pelvis, 1990–2021: analysis of data from the Global Burden of Disease Study 2021

Frontiers in Public Health
BackgroundFractures of the pelvis are significant orthopedic injuries associated with high morbidity, mortality, and substantial economic burden worldwide.MethodsThis study aimed to comprehensively analyze the disease burden of pelvic fractures globally ...
Jiyong Wei, Jiyong Wei, Dezhi He, Guipeng Lan, Minglian Xu, Jianfeng Guo, Yanni Lan, Shaohui Zong, Shaohui Zong   +8 more
doaj   +1 more source

Breaking the Debilitating Cycle: Pathophysiology, Assessment, and Multimodal Intervention of Secondary Debilitation After Hip Fracture in Older Adults—A Narrative Review

Orthopaedic Surgery, Volume 18, Issue 9, Page 1785-1803, September 2026.
This article provides a comprehensive overview of the pathophysiological mechanisms underlying “secondary debilitation after hip fracture,” discusses the clinical application of risk assessment tools, and presents a phased, stepwise intervention strategy aimed at interrupting the “vicious cycle.” ABSTRACT Hip fractures pose a serious threat to the ...
Wenyang Xu, Fan Xu, Maoqiang Fan, Yao Liu, Zhe Song   +4 more
wiley   +1 more source

Global, regional, and national burdens of congenital heart anomalies from 1990 to 2021, and projections to 2050

Frontiers in Pediatrics
BackgroundCongenital heart anomalies (CHAs) are the most prevalent birth defects, significantly impacting pediatric populations and healthcare systems worldwide.
Erdengqieqieke Ye, Erman Wu, Erman Wu, Tong Tang, Xiaolin La   +4 more
doaj   +1 more source

The global burden of mental, neurological and substance use disorders: an analysis from the Global Burden of Disease Study 2010. [PDF]

PLoS ONE, 2015
BACKGROUND:The Global Burden of Disease Study 2010 (GBD 2010), estimated that a substantial proportion of the world's disease burden came from mental, neurological and substance use disorders.
Harvey A Whiteford, Alize J Ferrari, Louisa Degenhardt, Valery Feigin, Theo Vos   +4 more
doaj   +1 more source

Burden of cardiovascular disease deaths, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life years (DALYs) attributable to overall and specific dietary risk factors in Australia, by sex, in1990 and 2019.

Burden of cardiovascular disease deaths, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life years (DALYs) attributable to overall and specific dietary risk factors in Australia, by sex, in1990 and 2019.
George Siopis (15822194), Sheikh Mohammed Shariful Islam (6195494), Elena S. George (12595798), Rachel R. Huxley (12032179), Riaz Uddin (9715154), Sarah A. McNaughton (8622846), Ralph Maddison (39626), Sebastian V. Moreno (17803834), Katherine M. Livingstone (9735919)   +8 more
core   +1 more source

BeBOD estimates of incidence, prevalence, and years lived with disability for 57 cancer types, 2004-2021

, 2023
<p><strong>Belgian National Burden of Disease Study</strong></p><p><strong>Estimates of the morbidity burden of disease for 57 cancer sites</strong></p><p><i>Incidence</i></p><p ...
Devleesschauwer, Brecht, Silversmit, Geert, De Pauw, Robby, Gorasso, Vanessa, Guariguata, Leonor   +4 more
core   +1 more source

Trends, prevalence, incidence, and disability-adjusted life years of anorexia nervosa and bulimia nervosa in Iran: Global Burden of Disease Study

Eating and Weight Disorders
Objectives Given the significant prevalence of mental health disorders in Iran, this research seeks to examine various epidemiological aspects related to eating disorders (ED).
Sohrab Amiri, Seyed Morteza Hosseini
doaj   +1 more source