Results 61 to 70 of about 166,885,457 (298)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Smoking-attributable mortality and expected years of life lost in Canada 2002: conclusions for prevention and policy

, 2007
Cigarette smoking is one of the most important risk factors for burden of disease. Our objective was to estimate the smoking-attributable deaths and the years of life lost for Canada 2002. For Canada in 2002, 37,209 of all deaths aged 0 to 80+ years were
Popova, Svetlana, Baliunas, Dolly, Taylor, Benjamin, Kaiserman, Murray, Patra, Jayadeep, Rehm, Jürgen   +5 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Premature mortality and years of potential productive life lost due to HPV-attributable cancers in Brazil and Mexico: 2011 Versus 2023

Human Vaccines & Immunotherapeutics
Human papillomavirus (HPV) remains a preventable cause of cancer mortality in Latin America. Using 2011 and 2023 mortality data from Brazil and Mexico, we estimated HPV-attributable cancer deaths, years of life lost (YLL), average YLL, and years of ...
Paula Cristina Pungartnik, Cintia Irene Parellada, Daniela Mayumi Usuda Prado Rocha, Rodrigo Gonçalves Queijo, Ana Luiza Bierrenbach, Juan Carlos Orengo   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Risk factors of fatal occupational accidents in Iran

Annals of Occupational and Environmental Medicine, 2018
Background Occupational accidents are of most important consequences of globalization in developing countries. Therefore, investigating the causes of occupational accidents for improving the job situation and making operational policy is necessary.
Hadi Asady, Mehdi Yaseri, Mostafa Hosseini, Morvarid Zarif-Yeganeh, Mahmoud Yousefifard, Mahin Haghshenas, Parisa Hajizadeh-Moghadam   +6 more
doaj   +1 more source

The global burden of neglected zoonotic diseases: Current state of evidence

One Health, 2023
The majority of emerging infectious diseases are zoonoses, most of which are classified as “neglected”. By affecting both humans and animals, zoonoses pose a dual burden.
Carlotta Di Bari, Narmada Venkateswaran, Christina Fastl, Sarah Gabriël, Delia Grace, Arie H. Havelaar, Ben Huntington, Grace T. Patterson, Jonathan Rushton, Niko Speybroeck, Paul Torgerson, David M. Pigott, Brecht Devleesschauwer   +12 more
doaj   +1 more source

Person Years of Life Lost and Average Years of Life Lost of injury by gender in China, 2004–2010.

, 2014
Person Years of Life Lost and Average Years of Life Lost of injury by gender in China, 2004–2010.
Chenghua Jiang (510383), Zhiqiang Li (102723), Jie Zhang (64655), Xucheng Li (510382), Jue Li (339674), Liang Zheng (206933), Lijuan Zhang (36878)   +6 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Ambient air pollution and years of life lost in Ningbo, China [PDF]

, 2016
To evaluate the burden of air pollution on years of life lost (YLL) in addition to mortality, we conducted a time series analysis based on the data on air pollution, meteorological conditions and 163,704 non-accidental deaths of Ningbo, China, 2009–2013.
Shen, Yueping, Zhang, Yuelun, Tang, Jinling, Qian, Xujun, Zhu, Shankuan, Fu, Xiaohong, Wang, Yong, Xu, Zhiwei, Mao, Chen, He, Tianfeng, Yang, Zuyao, Liu, Tao, Xu, Guozhang   +12 more
core   +1 more source