Results 61 to 70 of about 174,241,193 (307)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Premature mortality and years of potential productive life lost due to HPV-attributable cancers in Brazil and Mexico: 2011 Versus 2023

Human Vaccines & Immunotherapeutics
Human papillomavirus (HPV) remains a preventable cause of cancer mortality in Latin America. Using 2011 and 2023 mortality data from Brazil and Mexico, we estimated HPV-attributable cancer deaths, years of life lost (YLL), average YLL, and years of ...
Paula Cristina Pungartnik, Cintia Irene Parellada, Daniela Mayumi Usuda Prado Rocha, Rodrigo Gonçalves Queijo, Ana Luiza Bierrenbach, Juan Carlos Orengo   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Years of life lost due to infectious diseases in Poland.

, 2017
PurposeAn evaluation of mortality due to infectious diseases in Poland in 1999-2012 and an analysis of standard expected years of life lost due to the above diseases.MethodsThe study material included a database created on the basis of 5,219,205 death ...
Malgorzata Pikala, Elzbieta Dziankowska-Zaborszczyk, Irena Maniecka-Bryla, Marek Bryla, Pawel Bryla, Bryla Pawel, Bryla Marek, Dziankowska-Zaborszczyk Elzbieta, Pikala Malgorzata, Maniecka-Bryla Irena   +9 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Risk factors of fatal occupational accidents in Iran

Annals of Occupational and Environmental Medicine, 2018
Background Occupational accidents are of most important consequences of globalization in developing countries. Therefore, investigating the causes of occupational accidents for improving the job situation and making operational policy is necessary.
Hadi Asady, Mehdi Yaseri, Mostafa Hosseini, Morvarid Zarif-Yeganeh, Mahmoud Yousefifard, Mahin Haghshenas, Parisa Hajizadeh-Moghadam   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Life expectancy estimates in the Netherlands used for calculation of years-of-life-lost (YLL).

, 2012
Life expectancy estimates in the Netherlands used for calculation of years-of-life-lost (YLL).
Liselotte van Asten (185299), Adam Meijer (85041), Frederika Dijkstra (185308), Wim van der Hoek (53746), Wilfrid van Pelt (185301), Marianne A. B. van der Sande (185315), Carel Harmsen (185311), Nico J. D. Nagelkerke (141028), Mirjam Kretzschmar (27309), Cees C. van den Wijngaard (185298), Gé A. Donker (185305), Marion P. G. Koopmans (185300), Alies van Lier (185303), Cornelia C. H. Wielders (185302)   +13 more
core   +1 more source

Years of potential life lost, proportions and means by causes, Cabo Verde, 2018.

, 2023
Years of potential life lost, proportions and means by causes, Cabo Verde, 2018.
Lara Ferrero Gomez (9403810), Ngibo Mubeta Fernandes (14773849), Maria da Luz Lima Mendonça (10511989)   +2 more
core   +1 more source

COVID-19 burden in Iran: disability-adjusted life years analysis from hospital data, 2020–2021

Archives of Public Health
Background The burden of disease based on disability-adjusted life years (DALYs) is one of the internationally accepted metrics for assessing the impact of a disease or injury on population health.
Soheila Damiri, Mahshad Goharimehr, Mohammad Mahdi Nasehi, Mohammad Effatpanah, Zahra Shahali, Hossein Ranjbaran, Rajabali Daroudi   +6 more
doaj   +1 more source