Results 71 to 80 of about 174,241,193 (307)

Social gradients in years of potential life lost in Ireland [PDF]

The European Journal of Public Health, 2003
Background: The study of mortality differentials by class or socio-economic group is underdeveloped in Ireland in comparison to other countries. The work that has been done has used a standardized mortality ratio (SMR) methodology to measure deaths. There has been no previous work exploring the social gradient in years of potential life lost (YPLL) in ...
openaire   +3 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Annual estimates of influenza-attributed life years lost, quality adjusted life years (QALYs) lost and monetary value of QALYs lost by risk and age group in millions of US Dollars averaged over five respiratory seasons.

, 2017
Annual estimates of influenza-attributed life years lost, quality adjusted life years (QALYs) lost and monetary value of QALYs lost by risk and age group in millions of US Dollars averaged over five respiratory seasons.
Robertus van Aalst (3611738), Jason K. H. Lee (3611741), Yinong Young-Xu (515753), Ayman Chit (776713), Ellyn Russo (3611744)   +4 more
core   +1 more source

Years of life lost (YLLs) due to premature mortality, disability, and total DALYs.

, 2022
Years of life lost (YLLs) due to premature mortality, disability, and total DALYs.
Andrés Pichon-Riviere (3213861), Agustín Casarini (12184645), Alfredo Palacios (7316909), Chukwuka Onyekwena (12184657), Adedeji Adeniran (12184648), Federico Rodriguez Cairoli (10321114), Ariel Bardach (202568), Natalia Espinola (9189954), Marco Castradori (12184651), Precious Akanonu (12184654)   +9 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Total temporary and lifelong years lived with disability, years of life lost and disability-adjusted life-years per 1-year interval (2010–2012).

, 2014
Total temporary and lifelong years lived with disability, years of life lost and disability-adjusted life-years per 1-year interval (2010–2012).
Juanita A. Haagsma (237271), Suzanne Polinder (360134), Annemieke C. Scholten (649069), Martien J. M. Panneman (347330), Ed F. van Beeck (347331)   +4 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Potential years of life lost (PYLL) caused by asbestos-related diseases in the world

, 2013
[[abstract]]Background: We applied the well-established, but rather under-utilized, indicator of Potential Years of Life Lost (PYLL) to estimate the global burden of mesothelioma and asbestosis.
Diandini, R;Takahashi, K;Park, EK;Jiang, Y;Movahed, M;Le, GV;Lee, LJH;Delgermaa, V;Kim, R
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source