Results 71 to 80 of about 166,885,457 (298)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

COVID-19 burden in Iran: disability-adjusted life years analysis from hospital data, 2020–2021

Archives of Public Health
Background The burden of disease based on disability-adjusted life years (DALYs) is one of the internationally accepted metrics for assessing the impact of a disease or injury on population health.
Soheila Damiri, Mahshad Goharimehr, Mohammad Mahdi Nasehi, Mohammad Effatpanah, Zahra Shahali, Hossein Ranjbaran, Rajabali Daroudi   +6 more
doaj   +1 more source

Social gradients in years of potential life lost in Ireland [PDF]

The European Journal of Public Health, 2003
Background: The study of mortality differentials by class or socio-economic group is underdeveloped in Ireland in comparison to other countries. The work that has been done has used a standardized mortality ratio (SMR) methodology to measure deaths. There has been no previous work exploring the social gradient in years of potential life lost (YPLL) in ...
openaire   +3 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A Good Life in Later Years: A Co-Produced Research Project [PDF]

, 2017
The ‘A Good Life Project’ evolved as a co-production study looking at quality of life in later years. Funded by the Life Changes Trust, and in partnership with Age Scotland, researchers from the University of Stirling worked hand in hand with
Gibson, Grant, Robertson, Jane, Greasley-Adams, Corinne, McCall, Vikki   +3 more
core  

Years of life lost due to infectious diseases in Poland.

, 2017
PurposeAn evaluation of mortality due to infectious diseases in Poland in 1999-2012 and an analysis of standard expected years of life lost due to the above diseases.MethodsThe study material included a database created on the basis of 5,219,205 death ...
Malgorzata Pikala, Elzbieta Dziankowska-Zaborszczyk, Irena Maniecka-Bryla, Marek Bryla, Pawel Bryla   +4 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Ambient Temperature and Years of Life Lost: A National Study in China

, 2021
Although numerous studies have investigated premature deaths attributable to temperature, effects of temperature on years of life lost (YLL) remain unclear.
Zhou, C, Jin, D, Liu, T, Xu, Y, Li, J, Xu, X, Lin, L, Huang, B, Wang, L, Hou, Z, Zhang, H, Hu, R, Xiao, Y, et al., Rutherford, S   +14 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source