Results 161 to 170 of about 336,080 (364)
Unwrapping the Ciliary Coat: High‐Resolution Structure and Function of the Ciliary Glycocalyx
Advanced Science, EarlyView.The ciliary membrane is decorated in glycosylated proteins that define the interaction of the cilium with its environment. The main component of the ciliary coat of the green alga Chlamydomonas reinhardtii, FMG1, is characterized by cryo‐electron microscopy, proteomics, and live cell microscopy with flow‐based adhesion assays.
Lara M. Hoepfner +8 more
wiley +1 more source
Advanced Science, EarlyView.Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley +1 more source
Beyond the GTP‐cap: Elucidating the molecular mechanisms of microtubule catastrophe
BioEssays, Volume 45, Issue 1, January 2023., 2023 Microtubule dynamics are essential for myriad cellular processes. The switching between microtubule growth and shrinkage is traditionally explained by the loss of a protective “cap” of GTP‐bound tubulin subunits from the growing microtubule end. New research shows that features beyond the nucleotide content at the growing end impact microtubule ...
Veronica J. Farmer, Marija Zanic
wiley +1 more source
A New Acidic Ultraviolet Absorbing Substance Containing Amino Acids in Bacteria, Yeasts and Spore Preparations. [PDF]
, 1959 Jon Jonsen +5 more
openalex +1 more source
A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges
Advanced Science, EarlyView.A general model of inheriting changes that are acquired during the lifetime of individuals demonstrates tremendous benefits to the population, including escape from extinction in changing environments. Contrasting the model with experimental data shows that inheritance of acquired changes enables rapid adaptation to unforeseen challenges, and accounts ...
Dino Osmanović +2 more
wiley +1 more source
On the structure of proten-protein interaction networks [PDF]
arXiv, 2003 We present a simple model for the underlying structure of protein-protein pairwise interaction graphs that is based on the way in which proteins attach to each other in experiments such as yeast two-hybrid assays. We show that data on the interactions of human proteins lend support to this model.
arxiv
Assessment and Mitigation of CRISPR‐Cas9‐Induced Nontargeted Translocations
Advanced Science, EarlyView.Various inverted repeat elements are dispersed throughout genomes. This study reveals that these elements can cause significant chromosomal rearrangements when CRISPR editing occurs in their proximity. The risk can be mitigated by incorporating inverted repeat‐homologous segments into the CRISPR system, which represents a promising strategy for ...
Zhiyang Hou +6 more
wiley +1 more source
Biotechnology Journal, Volume 18, Issue 1, January 2023., 2023 Graphical Abstract and Lay Summary The heterogenous production conditions in large‐scale bioreactors cause scale‐up problems, such as reduced biomass or product yield, to occur during bioprocesses. In this study, we designed a two‐compartment scale‐down reactor and used it to simulate large‐scale heterogenous production conditions, allowing us to ...
Florian Mayer +7 more
wiley +1 more source
Advanced Science, EarlyView.The target of rapamycin (TOR) complex is a central plant growth regulator. Here, the protein–protein interactions underlying its various functions are mapped by pupylation‐based proximity‐labeling in Arabidopsis, using TOR complex subunits LST8‐1 and RAPTOR1, alongside TOR inhibitor FK506‐binding protein, as baits.
Shuai Zheng +9 more
wiley +1 more source