Results 191 to 200 of about 148,524 (302)

An Effector TaCRVP From Tuta Absoluta Oral Secretion Impairs H2O2‐Mediated Plant Defense by Targeting Tomato SlCAT2

Advanced Science, EarlyView.
The Tuta absoluta salivary effector TaCRVP subverts tomato immunity by hijacking host catalase SlCAT2. Through a sophisticated dual mechanism, TaCRVP simultaneously promotes SlCAT2 tetramerization for activation and blocks its SlAdBiL‐mediated degradation for stabilization.
Jianquan Yan, Youdan Zhang, Zhujun Wang, Huatao Tang, Huiping Liu, Zi Chen, Shuai Liu, Jiayi Shi, Lu Peng, Youming Hou   +9 more
wiley   +1 more source

Mixed-fermentation effects of co-fermentation with <i>Hanseniaspora uvarum</i> and <i>Saccharomyces cerevisiae</i> on the flavor quality of Ziyan tea wine. [PDF]

Food Chem X
Hua Y, Ling L, Xia X, Zhao Y, Chen Y, Lin L, Xu W.   +6 more
europepmc   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Determination of the peroxisomal proteome of pathogenic stage <i>Histoplasma capsulatum</i>. [PDF]

mBio
Brechting PJ, Rappleye CA.
europepmc   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Practices of Antifungal Prophylaxis Among Italian Pediatric Oncology-Hematology Centers. [PDF]

EJHaem
Colli M, Grasso A, Spadea M, Compagno F, Chiusaroli L, Muggeo P, Pancaldi A, Mura R, Onofrillo D, De Santis R, Mongelli B, Barone A, Rinieri S, Coccia P, Ricci E, Faraci M, D'Amico MR, Galaverna F, Gasperini P, Brescia L, Colombini A, Masetti R, Baccelli F, Cesaro S.   +23 more
europepmc   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects. [PDF]

Synth Syst Biotechnol
Zhang L, Fan Y, Shi W, Zhou X.
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Identification of Clinically Relevant Yeasts from Avian Isolates Using API ID32C, MALDI-TOF MS, and ITS Sequencing: Potential Relevance from a One Health Perspective. [PDF]

Vet Sci
Acosta-Hernández B, Cabrera Guerle N, García PL, Armas Carballo O, Ojeda-Vargas MDM, Garcia-Bustos V, Real Valcárcel F, Déniz Suárez S, Díaz Rodríguez EL, Rosario Medina I.   +9 more
europepmc   +1 more source