Results 111 to 120 of about 639,780 (268)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Evaluación agronómica de cuatro variedades mejoradas de arroz en distintas épocas de siembra

Agrisost, 2016
Resumen Con el objetivo de evaluar el desempeño agronómico de cuatro variedades de arroz en distintas época de siembra en condiciones de aniego permanente, utilizando la siembra directa, se realizó un estudio en la Estación Territorial de ...
Genry Hernández Carrillo, Amalia Moredo Alvare, Déborah González Viera   +2 more
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Screening of Sunflower Hybrids Using Physiological and Agronomic Traits

Agronomy
Researching the photosynthetic activity of sunflower (Helianthus annuus L.) is essential for understanding how different genotypes respond to environmental conditions and utilise solar energy for growth and productivity.
Antonela Markulj Kulundžić, Dario Iljkić, Ivana Varga   +2 more
doaj   +1 more source

QTL mapping of yield component traits on bin map generated from resequencing a RIL population of foxtail millet (Setaria italica). [PDF]

BMC Genomics, 2020
Liu T, He J, Dong K, Wang X, Wang W, Yang P, Ren R, Zhang L, Zhang Z, Yang T.   +9 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Rhizobia Inoculation Enhances Soybean Productivity Through Optimization of Root and Leaf Traits in the Huang‐Huai‐Hai Plain

Food and Energy Security
Rhizobia inoculation is an effective strategy to enhance soybean yield for ensuring food and feed security, yet its synergistic effects with nitrogen (N) application and the physiological mechanisms remain unclear in the Huang‐Huai‐Hai Plain, a major ...
Lei Yang, Xiaofei Chen, Wenjun Jin, Dagang Wang, Changfu Tian, Chong Xu, Lingcong Kong, Zhiping Huang, Yifei Lu, Chang Liu, Zhaohai Zeng, Wenfeng Chen, Xiangbei Du   +12 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source