Results 191 to 200 of about 6,883,757 (381)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene.

Metabolic Engineering, 2019
Tian Ma, B. Shi, Ziling Ye, Xiaowei Li, Min Liu, Yun Chen, Jiang Xia, J. Nielsen, Z. Deng, Tiangang Liu   +9 more
semanticscholar   +1 more source

Engineering salt-tolerantBrassicaplants: Characterization of yield and seed oil quality in transgenic plants with increased vacuolar sodium accumulation

, 2001
Hongxia Zhang, Joanna N. Hodson, John P. Williams, Eduardo Blumwald   +3 more
openalex   +1 more source

Metabolic engineering strategies for optimizing acetate reduction, ethanol yield and osmotolerance in Saccharomyces cerevisiae [PDF]

, 2017
Ioannis Papapetridis, Marlous van Dijk, Antonius J. A. van Maris, Jack T. Pronk   +3 more
openalex   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Quantum evolution of mixed states and performance of quantum heat engines [PDF]

arXiv
We introduce a technique for calculation the density operator time evolution along the lines of Heisenberg representation of quantum mechanics. Using this technique, we find the exact solution for the evolution of two and three coupled harmonic oscillators initially prepared in thermal states at different temperatures. We show that such systems exhibit
arxiv  

Structure-Guided Engineering of Prenyltransferase NphB for High-Yield and Regioselective Cannabinoid Production

, 2022
Kevin Lim, Yossa Dwi Hartono, Bo Xue, Maybelle Kho Go, Hao Fan, Wen Shan Yew   +5 more
openalex   +1 more source

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Meeting the Global Food Demand of the Future by Engineering Crop Photosynthesis and Yield Potential

Cell, 2015
S. Long, Amy Marshall-Colón, Xinguang Zhu   +2 more
semanticscholar   +1 more source

Metabolic Engineering of Starch for Enhanced Plant Productivity and Yields

, 2003
Kelly Gibson, Seon‐Kap Hwang, Gerald E. Edwards, Thomas W. Okita, Chikako Kato, Hirokazu Matsui, Ito H   +6 more
openalex   +2 more sources