Results 191 to 200 of about 1,733,424 (331)

Germline Cas9 Expression Yields Highly Efficient Genome Engineering in a Major Worldwide Disease Vector,Aedes aegypti [PDF]

, 2017
Ming Li, Michelle Bui, Ting Yang, Bradley J. White, Omar S. Akbari   +4 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Unlocking the potential of endophytes in enhancing plant secondary metabolite biosynthesis. [PDF]

Biochem Biophys Rep
Alum EU, Nwuruku OA, Uti DE, Echegu DA, Ugwu OP, Egba SI, Agu PC, Aja PM.   +7 more
europepmc   +1 more source

De novo biosynthesis of quercetin in Yarrowia Lipolytica through systematic metabolic engineering for enhanced yield [PDF]

Yuxing Dong, Wenping Wei, Mengfan Li, Tao Qian, Jiayun Xu, Xiaohe Chu, Bang‐Ce Ye   +6 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Metabolic Engineering of Yeasts for the Production of the Triterpene Squalene: Current Status and Future Prospective. [PDF]

Microorganisms
Zuo S, Tan X, Mao J, Hu F, Chen J, Fan L, Lu Q, Zhao Y, Wang Y, Xiao Z, Zhang S, Shan Y, Liu J, Fu F.   +13 more
europepmc   +1 more source

Rotation of soybean and Corydalis yanhusuo enhances yield and active compounds of C. yanhusuo via soil nutrient optimisation and rhizosphere microbiome engineering [PDF]

Jia Liu, Yuan Qiang, Kejie Zhang, Xiaoxiao Sheng, Zixuan Zhu, Ning Sui, Hui Wang   +6 more
openalex   +1 more source

Yield improvement of epothilones in Burkholderia strain DSM7029 via transporter engineering [PDF]

, 2018
Chenlang Liu, Fangnan Yu, Qingshu Liu, Xiaoying Bian, Shengbiao Hu, Huansheng Yang, Yulong Yin, Yuezhong Li, Yuemao Shen, Liqiu Xia, Qiang Tu, Youming Zhang   +11 more
openalex   +1 more source

Engineering of Soybean Plants with Improved Grain Yield, Seed Oil and Drought Tolerance

, 2022
Jin Yang, Tingting Mao, Zigui Geng, Wenwen Xue, Lan Ma, Yu Jin, Pan Guo, Zitong Qiu, Limin Wang, Chunyan Yu, Yuting Sheng, Juan Zhang, Hongxia Zhang   +12 more
openalex   +1 more source