Results 191 to 200 of about 1,794,891 (330)

Rhizosphere Microbiome Engineering for Climate-Smart Agriculture: From Synthetic Consortia to Precision Decision Support. [PDF]

Microorganisms
Fouad N, Elzayat EM, Amr D, El-Khishin DA, Radwan KH, Youssef A, Khalaf AA, Ahmed HA, Radwan EH, Tawkaz S, Baum M.   +10 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

An Acetyl-CoA-Gated Metabolic Checkpoint Links Precursor Supply to Cordycepin Biosynthesis in <i>Cordyceps militaris</i>. [PDF]

Curr Issues Mol Biol
Zhang H, Yang D, Yang G, Luo S, Lu P, Xie G, Song Y, Yang J, Liu L, Fan H, Lao W, Vriesekoop F.   +11 more
europepmc   +1 more source

Boosting plant oil yields: the role of genetic engineering in industrial applications [PDF]

Nima Hajinajaf, Ahmad Fayyazbakhsh, Sara Kamal Shahsavar, Forough Sanjarian, Hassan Rahnama   +4 more
openalex   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Structure-Guided Engineering of a MultifunctionalGlycosidase for Exclusive High-Yield Production of Ginsenoside F1from Panax Notoginseng

Yuaner Sui (22414324), Bin Wei (49482), Zichen Wang (2473054), Hao Liang (188241)   +3 more
openalex   +1 more source

Ceria Engineering in Nickel Catalysts to Improve Ch4 Selectivity and Yield for Co Methanation

, 2022
Wenshuai Zhang, Yang Liu, Yajun Dong, Yanheng Hao, Lin Chen, Jiayu Li, Hong Wang, Shanghong Zeng   +7 more
openalex   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Dynamic metabolic modeling uncovers systems-level strategies to simultaneously maximize levan yield and substrate efficiency in Bacillus subtilis LY7.16. [PDF]

PLoS Comput Biol
Hakim MN, Chiewchankaset P, Kalapanulak S, Waeonukul R, Tiangpook S, Saithong T.   +5 more
europepmc   +1 more source

Engineering E. coli recombinant strains for high yield production of Burkholderia pseudomallei specific antigens

, 2019
Yu. A. Kuzyutina, И. Б. Захарова, Д. В. Викторов   +2 more
openalex   +2 more sources