Results 41 to 50 of about 1,248,294 (182)

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Engineering Sexless Seeds as a Path to High-Yield Crops

PLoS Biology, 2009
Global food security is hampered by the fact that today's high-yield grains are hybrids, with seeds that fail to retain all of the desired traits, necessitating ongoing rounds of breeding and selection. In contrast, seeds produced asexually are, effectively, clones of the mother plant and so retain the desired traits, greatly streamlining their ...
openaire   +5 more sources

The Need, Benefits, and Demonstration of a Minimization Principle for Excited States

, 2015
It is shown that the standard methods of computing excited states in truncated spaces must yield wave functions that, beyond truncation, are in principle veered away from the exact, and a remedy is demonstrated via a presented functional, F$_n$, obeying ...
Bacalis, Naoum C.
core   +1 more source

From fly-by-wire to drive-by-wire: Safety implications of automation in vehicles [PDF]

, 1996
The purpose of this paper is to critically review the current trend in automobile engineering toward automation of many of the functions previously performed by the driver.
Anderson, Bainbridge, Barber, Barley, Billings, Boehm-Davies, Fitts, Hackman, Marsden, Marsden, McLoughlin, Meister, Neville A. Stanton, Norman, Philip Marsden, Price, Quest, Reason, Schlegel, Singleton, Stanton, Stokes, Swain, United Nations, Webster, Weiner, Weiner, Weiner, Wickens, Wilde, Wilde, Wilde   +31 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Ribosome Pool Engineering Increases Protein Biosynthesis Yields

ACS Central Science
The biosynthetic capability of the bacterial ribosome motivates efforts to understand and harness sequence-optimized versions for synthetic biology. However, functional differences between natively occurring ribosomal RNA (rRNA) operon sequences remain poorly characterized. Here, we use an in vitro ribosome synthesis and translation platform to measure
Camila Kofman, Jessica A. Willi, Ashty S. Karim, Michael C. Jewett   +3 more
openaire   +3 more sources

Developing Genetic Engineering Techniques for Control of Seed Size and Yield

International Journal of Molecular Sciences, 2022
Many signaling pathways regulate seed size through the development of endosperm and maternal tissues, which ultimately results in a range of variations in seed size or weight. Seed size can be determined through the development of zygotic tissues (endosperm and embryo) and maternal ovules. In addition, in some species such as rice, seed size is largely
Alam, Intikhab, Batool, Khadija, Huang, Yuanyuan, Liu, Junjie, Ge, Liangfa   +4 more
openaire   +2 more sources

Prediction of microgeometrical influences on micropitting fatigue damage on 32CrMoV13 steel [PDF]

, 2013
Dr Fabre's sabbatical period at the Cardiff School of Engineering allowed the research to be conducted. Thanks are due to the M2P department of Arts et Métiers ParisTech, to Arts et Métiers ParisTech—Aix en Provence, and to the MécaSurf laboratory for ...
BARRALLIER, Laurent, DESVIGNES, Marc, EVANS, H-P, FABRE, Agnès, SHARIF, K.J   +4 more
core   +5 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source