Results 71 to 80 of about 6,883,757 (381)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Biotechnology and bioeconomy of complex traits in crop plants
BioTechnologia, 2017 Most important crop productivity traits, such as yield under normal and environmental stress conditions, are determined by a large number of genes, each with a small phenotypic effect.
Jan Antoni Rafalski
doaj +1 more source
ACS Synthetic Biology, 2017 Attempts at microbial production of the chemotherapeutic agent Taxol (paclitaxel) have met with limited success, due largely to a pathway bottleneck resulting from poor product selectivity of the first hydroxylation step, catalyzed by taxadien-5a ...
S. Edgar +4 more
semanticscholar +1 more source
Direct solutions to tropical optimization problems with nonlinear objective functions and boundary constraints [PDF]
, 2013 We examine two multidimensional optimization problems that are formulated in terms of tropical mathematics. The problems are to minimize nonlinear objective functions, which are defined through the multiplicative conjugate vector transposition on vectors
Krivulin, Nikolai, Zimmermann, Karel
core
The parameterisation of turbulence in the marine environment [PDF]
, 2016 There are many problems in the fields of flow modelling around structures and tidal stream energy yield analysis which require a thorough understanding of the turbulent and time-averaged flow speeds in marine environments.
Hardisty, Jack, Jennings, Ross
core +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
, 2015 It was difficult for me to understand the meaning of "engineering" as used in the title of my speech. I asked Dr. Haskins who told me that the term engineering is used here because one traditional role of the engineer has been the application of scientific principles in the solution of practical problems, and that in this case we want to consider the ...
openaire +2 more sources
Experimental Evaluation of Hysteretic Behavior of Rhombic Steel Plate Dampers
Advances in Mechanical Engineering, 2014 Rhombic mild-steel plate damper (also named rhombic added damping and Stiffness (RADAS)) is a newly proposed and developed bending energy dissipation damper in recent years, and its mechanical properties, seismic behavior, and engineering application ...
Qiang Han +4 more
doaj +1 more source
Biosynthesis and metabolic engineering of 1-hydroxyphenazine in Pseudomonas chlororaphis H18
Microbial Cell Factories, 2021 Background 1-Hydroxyphenazine (1-OH-PHZ) is a phenazine microbial metabolite with broad-spectrum antibacterial activities against a lot of plant pathogens. However, its use is hampered by the low yield all along.
Yupeng Wan +3 more
doaj +1 more source
, 1977 Widely used constitutive laws for engineering materials assume plastic incompressibility, and no effect on yield of the hydrostatic component of stress. However, void nucleation and growth (and thus bulk dilatancy) are commonly observed in some processes
A. Gurson
semanticscholar +1 more source