Results 71 to 80 of about 1,794,891 (330)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Deep tillage tool optimization by means of finite element method: Case study for a subsoiler tine [PDF]
, 2010 Technologies and computer capacity currently available allow us to employ design software and numerical methods to solve complicated problems in very wide disciplines of engineering. It is also important for researches in agriculture.
Akinci, Ibrahim +5 more
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Ribosome Pool Engineering Increases Protein Biosynthesis Yields
ACS Central ScienceThe biosynthetic capability of the bacterial ribosome motivates efforts to understand and harness sequence-optimized versions for synthetic biology. However, functional differences between natively occurring ribosomal RNA (rRNA) operon sequences remain poorly characterized. Here, we use an in vitro ribosome synthesis and translation platform to measure
Camila Kofman +3 more
openaire +3 more sources
Biotechnology and bioeconomy of complex traits in crop plants
BioTechnologia, 2017 Most important crop productivity traits, such as yield under normal and environmental stress conditions, are determined by a large number of genes, each with a small phenotypic effect.
Jan Antoni Rafalski
doaj +1 more source
Analysis and Detection of Information Types of Open Source Software Issue Discussions
, 2019 Most modern Issue Tracking Systems (ITSs) for open source software (OSS) projects allow users to add comments to issues. Over time, these comments accumulate into discussion threads embedded with rich information about the software project, which can ...
Arya, Deeksha +3 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Air, Soil and Water ResearchMonitoring soil erosion is crucial for soil conservation policies, especially in tropical regions that are prone to water erosion. A 2-year field study was conducted to assess the impact of simple engineering approaches and poultry manure application on ...
Olanrewaju Hameed Ologunde +3 more
doaj +1 more source