Results 201 to 210 of about 41,970 (253)

The Semantics and Mechanisms of Enhancers and Promoters: "What Is True for <i>E. coli</i> Is True for the Elephant, Only More So". [PDF]

Annu Rev Biochem
Struhl K.
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Stereo-random oligonucleotides enable efficient recruitment of ADAR in vitro and in vivo. [PDF]

Nat Commun
Pfeiffer LS, Merkle T, Vogel P, Jarmoskaite I, Geisinger JM, Latifi N, Herrera-Barrera M, Zhang F, Groß L, Schlitz C, Hofacker DT, Lochmann C, Fumagalli D, Gackstatter S, Deisling V, Kay MA, Li JB, Stafforst T.   +17 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Effectiveness of computer-aided detection chest X-ray screening for improving tuberculosis diagnostic yield in Chinese primary healthcare settings: study protocol for a prospective cluster randomised controlled trial. [PDF]

BMJ Open
Yang X, Zhang H, Jiang W, Xin Y, Dai Z, Li Z, Xiong J, Sun R, Shao J, Yu J, Wang Y, Su X, Liu J, Li Z.   +13 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Community Assembly Mechanisms Underlying Divergent Responses of Indica and Japonica Rice Rhizosphere Microbiota to Drought Stress. [PDF]

Microb Ecol
Zhou S, Bi J, Zhou S, Luo L, Yan X, Zou J, Ji Y, Zhao S, Qiu J, Liu Z, Jiang J, Wang B, Liu X.   +12 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Mechanistic insights into yield enhancement of Chimonobambusa opienensis bamboo shoots driven by organic fertilizer combined with Azotobacter Chroococcum via soil nutrient-microbe-metabolite interactions. [PDF]

BMC Plant Biol
Fan W, Li S, Zhang Z, Long Z, Yang X, Chen W, Song X, Zhao X, Guan F, Cao Y, Fan S, Hu S.   +11 more
europepmc   +1 more source

A bacterial ally for nitrogen-fixing biofilm: enhancing the rhizosphere colonization of <i>Stutzerimonas stutzeri</i> A1501 with surfactin-producing <i>Bacillus velezensis</i> BRI3. [PDF]

Appl Environ Microbiol
Liu Y, Zhu M, Zou G, Yin C, Zhan Y, Lu W, Lin M, Ke X, Yan Y.   +8 more
europepmc   +1 more source