Results 81 to 90 of about 44,314 (257)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A preliminary analysis of the state of exploitation of the sardine, Sardina pilchardus (Walbaum, 1792), in the gulf of Annaba, East Algerian [PDF]

Animal Biodiversity and Conservation, 2009
This study was performed on 2,859 specimens of sardine, Sardina pilchardus, collected biweekly from November 2006 to October 2007. Samplings were carried out at the fishing port of Annaba where purse-seine methods are used for small-scale fishing at ...
Bedairia, A., Djebar, A. B.
doaj  

Problems in managing a slow-growing pikeperch (Sander lucioperca (L.)) population in Southern Finland

Knowledge and Management of Aquatic Ecosystems, 2011
Local fishery managers in Lake Sahajärvi tried to increase pikeperch yields by increasing the minimum allowed mesh size from 45 to 60 mm and size limit from 37 to 40 cm.
Milardi M., Lappalainen J., Malinen T., Vinni M., Ruuhijärvi J.   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Yield-per-recruit analysis of North Atlantic albacore (Thunnus Alalunga)

, 1985
In this paper, a new North Atlantic albacore demographic table is presentad, based on a surface catch-by age revision and new longline catch-by-age data. With the demographic table, a cohort analysis was applied for the 1959-1971 cohorts, and recruitment for the population and fishing mortality for each fishery were obtained.
González-Garcés-Santiso, A. (Alberto), Weber, E. (Ed)   +1 more
openaire   +1 more source

Preliminary yield per recruit analysis of the Indian Ocean yellowfin and bigeye fisheries

, 1986
Ce document présente des estimations de F par âge et par engin sur l'albacore et le patudo par les diverses pêcheries thonières de l'Océan Indien et tente d'analyser l'interaction théorique, en termes de production par recrue, entreengins de surface et palangre sur le stock d'albacore au moyen de simulations.
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source