Results 91 to 100 of about 30,193 (222)

Evaluating human cancer cell metastasis in zebrafish [PDF]

, 2013
BACKGROUND: In vivo metastasis assays have traditionally been performed in mice, but the process is inefficient and costly. However, since zebrafish do not develop an adaptive immune system until 14 days post-fertilization, human cancer cells can survive
David T White, Jeff S Mumm, John K Cowell, Steven Walker, Xiayang Xie, Yong Teng   +5 more
core   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis [PDF]

, 2000
Human testicular germ-cell tumors of young adults (TGCTs), both seminomas and nonseminomas, are characterized by 12p overrepresentation, mostly as isochromosomes, of which the biological and clinical significance is still unclear.
Beverloo, H.B. (Berna), Bokemeyer, C., Gillis, A.J.M. (Ad), Gurp, R.J.H.L.M. (Ruud) van, Looijenga, L.H.J. (Leendert), Mostert, M.C. (Marijke), Oorschot, M. van, Oosterhuis, J.W. (Wolter), Pompe, K., Roelofs, H., Stoop, J.A. (Hans), Zafarana, G. (Gaetano)   +11 more
core  

Tumor Microenvironments in Malignant Ovarian Germ Cell Tumors: MHC Class I Loss and T‐Cell Exhaustion in Dysgerminoma

Cancer Science, Volume 117, Issue 2, Page 566-575, February 2026.
Malignant ovarian germ cell tumor subtypes exhibit distinct tumor microenvironments. Dysgerminomas harbor abundant nonexhausted T cells, with progenitor exhausted T cells present in 60% of PD‐1–positive cases. However, MHC class I expression is lost across all analyzed subtypes, suggesting that restoring class I expression in dysgerminomas may enhance ...
Miya Nakashima, Takeshi Iwasaki, Yoshihiro Katayama, Masatoshi Shimo, Ken Takigawa, Naomi Shimada, Michiko Matsushita, Satoshi Kuwamoto, Shinya Sato, Masato Toya, Kohta Miyawaki, Koichi Akashi, Kiyoko Kato, Yoshinao Oda   +13 more
wiley   +1 more source

A clinicopathologic analysis of primary orbital yolk sac tumor

Chinese Journal of Contemporary Neurology and Neurosurgery, 2012
Objective On rare occasions, yolk sac tumor may arise from extragonadal sites. Orbit is an unusual location for the primary development of this tumor.
Ji⁃ying PENG, Yang LI, Bin LI, Bo⁃ning LUO, Zhi LI   +4 more
doaj  

Differential peritoneal resident macrophage depletion and omental milky spot disruption after high versus low clodronate‐loaded liposome dose treatment

Immunology &Cell Biology, Volume 104, Issue 2, Page 139-149, February 2026.
In this study, we found that intraperitoneal injection of a high (standard) clodronate‐loaded liposome dose induced persistent peritoneal macrophage depletion, paralleled by marked inflammation and compromised omental integrity. Conversely, low liposome dose caused transient macrophage depletion, low inflammation and no omental alterations, ensuring ...
Margarita Ferriz, Natalia Álvarez‐Ladrón, Alejandra Gutiérrez‐González, Marta H. Fernández‐Sesma, Ana Starešinčić, Carlos Ardavín   +5 more
wiley   +1 more source

Welfare assessment of turkeys (Meleagris gallopavo gallopavo) on farm

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract This Scientific Opinion assesses the welfare of turkeys of all ages (Meleagris gallopavo gallopavo) on farm in relation to the type and condition of the litter, type and availability of enrichment (including covered veranda and outdoor range), space allowance, concentrations of ammonia and carbon dioxide, effective environmental temperature ...
EFSA Panel Animal Health and Animal Welfare (AHAW), Søren Saxmose Nielsen, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dorea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Angel Miranda Chueca, Eleonora Nannoni, Romolo Nonno, | Karl Stahl, Jutta Berk, Joanna Marchewka, Nienke van Staaveren, Oana Maria Balmos, Chiara Fabris, Olaf Mosbach‐Schulz, Yves Van der Stede, Marika Vitali, Cristina Rojo Gimeno, Antonio Velarde, Anja Brinch Riber   +23 more
wiley   +1 more source

Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23. [PDF]

, 2017
Primordial germ cells (PGCs) are the earliest embryonic progenitors in the germline. Correct formation of PGCs is critical to reproductive health as an adult.
Chen, Di, Clark, Amander T, Gkountela, Sofia, Hennebold, Jon D, Liu, Wanlu, Orwig, Kyle E, Sosa, Enrique, Sukhwani, Meena   +7 more
core   +2 more sources

Clinical and neurophysiological changes in patients with pineal region expansions [Kliničke i neurofiziološke značajke u bolesnika s ekspanzivnim tvorbama pinealne regije] [PDF]

, 2013
In the last 20 years neurological and neurosurgical follow up of our patients with pineal region expansions (118 patients) pointed to certain clinical and neurophysiological regularities.
Hajnšek, Sanja, Lupret, Velimir, Mrak, Goran, Nanković, Sibila, Paladino, Josip, Petelin Gadže, Željka   +5 more
core  

Tumor do saco vitelino primário em retroperitônio

Revista do Colégio Brasileiro de Cirurgiões
A case of primary extragonadal yolk sac tumor in the retroperitoneum of a young adult male is reported. The symptoms were melena and weakness for two months. Radiologic studies suggested a retroperitoneal tumor infiltrating the duodenum, artery aorta and
Ascêncio Garcia Lopes Junior, José Pontes Júnior, Fernanda Cavalcanti, Paulo David Branco, Aldo Junqueira Rodrigues Júnior, Dario Birolini   +5 more
doaj   +1 more source