Results 71 to 80 of about 16,916 (186)
Diagnostic PathologyRationale SMARCB1 (INI1) deficient sinonasal carcinoma is a subtype of Switch/Sucrose nonfermentable (SWI/SNF) complex deficient sinonasal carcinoma, which is distinct from sinonasal undifferentiated carcinoma (SNUC) in 5th edition of the WHO ...
Shuang Ma +8 more
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Yolk sac tumor of endometrium: A case report and literature review
Taiwanese Journal of Obstetrics & Gynecology, 2019 Objective: To report a rare case of endometrial yolk sac tumor (YST) and review published cases of YST of the endometrium. Case report: A 68-year-old female presented with intermittent vaginal spotting for nine months.
Shih-Wen Lin +4 more
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Cell Proliferation, EarlyView.The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou +8 more
wiley +1 more source
SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC‐derived model
The FEBS Journal, EarlyView.In this study, we characterised the role of SHIP1 in regulating TREM2 signalling and global microglial myeloid functions using human‐induced pluripotent stem cell (hiPSC)‐derived macrophages. Knockout of SHIP1 (SHIP1 KO) in macrophages decreased inflammatory activation and levels of scavenger receptors. SHIP1 KO macrophages also exhibited reduced TREM2
Kim S. Martin +5 more
wiley +1 more source
A clinicopathologic analysis of primary orbital yolk sac tumor
Chinese Journal of Contemporary Neurology and Neurosurgery, 2012 Objective On rare occasions, yolk sac tumor may arise from extragonadal sites. Orbit is an unusual location for the primary development of this tumor.
Ji⁃ying PENG +4 more
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Immunology, EarlyView.Macrophage markers should be interpreted as context‐dependent biological readouts rather than deterministic cell identifiers. This Review proposes a multidimensional framework integrating lineage, identity, and functional state across complementary experimental modalities to enable a more accurate interpretation of macrophage heterogeneity.
Alessandro Palma
wiley +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Yolk sac tumor in the abdominal wall of an 18-month-old girl: a case report
Journal of Medical Case Reports, 2017 Background Pediatric germ cell tumors account for approximately 3.5 % of all childhood cancers for children under the age of 15 years. Up to one-third are extragonadal neoplasms.
Machiel van den Akker +4 more
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Histiocytes: Multifaceted Regulators of Health and Disease
Veterinary Clinical Pathology, EarlyView.ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
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The Journal of Physiology, EarlyView.Abstract figure legend Drug transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) at the blood–brain barrier (BBB) protect the rapidly developing fetal brain. We investigated the role of microRNA‐145‐5p (miR‐145‐5p) microRNA (miRNA) in regulating these key transporters in primary human fetal brain endothelial cells in vitro. We
Phetcharawan Lye +5 more
wiley +1 more source