Results 41 to 50 of about 29,985 (230)

Primary omental yolk sac tumor

Obstetrics & Gynecology Science, 2013
Extra-ovarian yolk sac tumor arising in the omentum is extremely rare. As yolk sac tumor originated from the omentum has been rarely reported, its clinical information is very limited. The authors encountered a case of yolk sac tumor originated from the omentum, and reported the case herein.
Lim, Seon Hwa, Kim, Yon Hee, Yim, Ga Won, Nam, Eun Ji, Kim, Young Tae, Kim, Sunghoon   +5 more
openaire   +3 more sources

Systematic assessment of HER2/neu in gynecologic neoplasms, an institutional experience. [PDF]

, 2016
BackgroundHER2/neu overexpression and/or amplification has been widely studied in a number of solid tumors, primarily in the breast. In gynecologic neoplasms, determination of HER2/neu status has not been well studied as a predictive biomarker in anti ...
Apple, Sophia K, Moatamed, Neda A, Ostrzega, Nora, Rao, Jian-Yu, Sullivan, Peggy S, Woo, Jennifer S   +5 more
core   +2 more sources

Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors [PDF]

, 2016
Background: Cisplatin (CDDP) resistance in testicular germ cell tumors (GCTs) is still a clinical challenge, and one associated with poor prognosis. The purpose of this work was to test pazopanib, an anti-tumoral and anti-angiogenic multikinase inhibitor,
Casanovas i Casanovas, Oriol, Condom i Mundó, Enric, García del Muro Solans, Xavier, Germà Lluch, José Ramón, Graupera i Garcia-Milà, Mariona, Juliachs Milà, Mercè, Piulats, Josep M., Vidal-Bel, August, Villanueva Garatachea, Alberto, Viñals Canals, Francesc   +9 more
core   +1 more source

Evaluating human cancer cell metastasis in zebrafish [PDF]

, 2013
BACKGROUND: In vivo metastasis assays have traditionally been performed in mice, but the process is inefficient and costly. However, since zebrafish do not develop an adaptive immune system until 14 days post-fertilization, human cancer cells can survive
David T White, Jeff S Mumm, John K Cowell, Steven Walker, Xiayang Xie, Yong Teng   +5 more
core   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. [PDF]

, 2018
Mechanisms that sense and regulate epithelial morphogenesis, integrity, and homeostasis are incompletely understood. Protease-activated receptor 2 (Par2), the Par2-activating membrane-tethered protease matriptase, and its inhibitor, hepatocyte activator ...
Balouch, Eaman, Barker, Adrian, Clay, Hilary, Coughlin, Shaun R, Hsiao, Chung-Der, Lam, Ian, Schepis, Antonino, Srinivasan, Yoga, Zheng, Yaowu   +8 more
core   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Successful yolk-sac tumor treatment with fertility-sparing partial oophorectomy

Gynecologic Oncology Reports, 2019
Yolk-sac tumors account for about 20% of ovarian germ cell tumors and occur predominantly in women below 35 years of age. Modern evidence-based treatment strategies have ensured long term post-treatment survival, but with increased survival, attention ...
Timothy N. Dunn, Kamyar Khazaeian, Donna M. Coffey, Jan Rohozinski, Ertug Kovanci, Creighton L. Edwards, Celestine S. Tung   +6 more
doaj   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source