Results 81 to 90 of about 30,193 (222)

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1622-1637, March 2026.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source

Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting [PDF]

, 2015
Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PEG10 (
Alsop, Amber, Graves, Jennifer, Ishino, Fumitoshi, Kaneko-Ishino, Tomoko, Kohara, Yuji, Kohda, Takashi, Narita, Takanori, Ono, Ryuichi, Pask, Andrew J, Renfree, Marilyn B, Shaw, Geoffrey, Suzuki, Shunsuke, Wang, Changshan   +12 more
core   +1 more source

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera   +2 more
wiley   +1 more source

Yolk sac tumor in children and the resulting biopsychosocial and spiritual aspects [PDF]

Yolk sac tumor is a rare germ cell tumor in children, accounting for only about 3.5% of pediatric cancers. However, the yolk sac tumor is a malignant tumor that requires chemotherapy, but the side effects of chemotherapy can have an impact on the ...
Hidayatullah, Lisal, Lenny M., Savitri, Irma   +2 more
core   +2 more sources

The present and future of serum diagnostic tests for testicular germ cell tumours. [PDF]

, 2016
Testicular germ cell tumours (GCTs) are the most common malignancy occurring in young adult men and the incidence of these tumours is increasing. Current research priorities in this field include improving overall survival for patients classified as ...
A Lorch, AJM Gillis, AJM Gillis, B Trabert, C Ackers, C Fung, C Kollmannsberger, C Kollmannsberger, CA Lago-Hernandez, D Gitlin, D Killock, D Raggi, DC Gilbert, DC Gilbert, DT Schneider, G Belge, G Cohn-Cedermark, G Daugaard, G Daugaard, GW Novotny, H Valadi, HS Haugnes, HS Haugnes, I Nishizono, I Syring, J Vuky, JR Germa, K Fizazi, K Fizazi, K Kobayashi, K Litchfield, KD Miller, KM Grigor, KP Dieckmann, L Rainen, LB Travis, M Bachner, M De Santis, M Spiekermann, M Spiekermann, MA Rijlaarsdam, Matthew J. Murray, ME Blohm, MJ Murray, MJ Murray, MJ Murray, MJ Murray, MJ Murray, MJ Murray, MJ Murray, MP Caby, MR van Dijk, Nicholas Coleman, P Chung, P Warde, PJ Johnson, PM Voorhoeve, R de Wit, R de Wit, R de Wit, R Venkitaraman, RA Huddart, RA Huddart, RA Huddart, RD Palmer, Robert A. Huddart, SA Bustin, SF Hain, T Kawakami, TD Gilligan, TV Tarin, VF Viprey, Z Bing   +72 more
core   +2 more sources

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

SMARCB1 (INI1)-deficient sinonasal carcinoma with yolk sac differentiation, a case of long-term clinical remission after multiple rounds of radiotherapy–a case report and literature review

Diagnostic Pathology
Rationale SMARCB1 (INI1) deficient sinonasal carcinoma is a subtype of Switch/Sucrose nonfermentable (SWI/SNF) complex deficient sinonasal carcinoma, which is distinct from sinonasal undifferentiated carcinoma (SNUC) in 5th edition of the WHO ...
Shuang Ma, Yuxin Xia, Minghui Wang, Zhongshan Luo, Lan Chen, Xiangyun Meng, Sophie Stuart, Endi Wang, Lian-He Yang   +8 more
doaj   +1 more source

A Clinical Guidance for the Management of Patients With Hepatoid Adenocarcinoma and A Case Series

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Hepatoid adenocarcinoma (HAC) is a rare extrahepatic tumor of non‐germ cell origin that morphologically resembles hepatocellular carcinoma (HCC). HAC has a propensity to metastasize to the liver and therefore may be mistaken for HCC. There is a lack of standardized treatment protocols, and further studies are needed to evaluate the benefit of ...
Christina Liava, Sudhakar Venkatesh, Michael S. Torbenson, Patrick S. Kamath, Moira Hilscher   +4 more
wiley   +1 more source

Yolk sac tumor in the abdominal wall of an 18-month-old girl: a case report

Journal of Medical Case Reports, 2017
Background Pediatric germ cell tumors account for approximately 3.5 % of all childhood cancers for children under the age of 15 years. Up to one-third are extragonadal neoplasms.
Machiel van den Akker, Dirk Vervloessem, An Huybrechs, Sabine Declercq, Jutte van der Werff ten Bosch   +4 more
doaj   +1 more source

Integrative cross‐tissue and spatially resolved single‐cell profiling uncovers tumour‐educated inflammatory remodelling of tissue‐resident macrophage ecosystem with immunotherapeutic prognostic significance in pan‐cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Pan‐cancer analysis reveals an inflammatory phenotype remodeling of tissue‐resident macrophages (iTRM) in the tumor microenvironment, which is associated with immunosuppression. Tissue‐resident macrophages and monocyte‐derived macrophages exhibit convergent differentiation toward a similar inflammatory phenotype. iTRM‐enriched ecosystems are associated
Weikai Wang, Zibin Chen, Yuhan Huang, Zhihao Hu, Peixin Zhu, Zhuoli Huang, Jingzhi Lv, Ziru Liao, Yuhui Zheng, Chen Wei, Baibing Guan, Yin Zeng, Xinyue Zhu, Yafei Yang, Guibo Li, Xin Jin, Xi Chen, Xiao Yang, Zikun Ma, Jianhua Yin   +19 more
wiley   +1 more source