Results 111 to 120 of about 2,813,214 (314)

3 Year Longıtudınal Changes In Cephalometrıc Skeletal Measurements Of Young Adults

Turkish Journal of Orthodontics, 1995
26 female and 24 male patients with an avarage chronological age of 18.96±132 years were selected in order to evaluate the skeletal changes in young adults.
Aslı Ender Telli, Bülent Haydar, Pınar Saatçi   +2 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A perspective on the burden of stroke among young adults in Africa

Discover Public Health
Stroke in young adults poses significant public health challenges, with deleterious impacts on individual morbidity and mortality. It significantly affects the productivity and growth of the patients’ families, as well as the communities in which they ...
Tejiri Napoleon, Deborah Akinrinde, Davies Oluwasijibomi Ogheneruona, Chioma Nnedinma Duru, Ucheobi Nonso Christopher, Sodiq Lawal, Emmanuela Ojoagefu Egwu, Chinwekene Okoye, Azubuike Nnagozie, Eleyinmi Oluwafunmilayo, Olawoyin Oluwatosin, Ayodeji Rejoice Oladejo, Olaniyi Michael Oladosu, Ojo Israel Ifeoluwa, Ogungbemi Evelyn Faith, Osunmakinwa Akinoluwa, Elete Shola Tabitha, Ishaq Oyeshina Sanusi   +17 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The Heat Is On: Climate Change Implications for Pregnant Women with Sickle Cell Disease

Women's Health Reports
Sickle cell disease (SCD), a serious, chronic blood disorder is the most common genetic blood disease in the United States affecting 100,000 people and disproportionately affecting the African American population.
Rachelle Chanmany Pastor, Lisa Roberts, Akshat Jain, Shan Tamares   +3 more
doaj   +1 more source

Feasibility of Mindfulness-Based Stress Reduction for older adolescents and young adults with poorly controlled type 1 diabetes

Health Psychology and Behavioral Medicine, 2018
Objective The purpose of the study was to assess the acceptability and feasibility of Mindfulness-Based Stress Reduction (MBSR), a group-delivered intervention, to reduce stress and improve illness management among urban, older adolescents, and young ...
Deborah A. Ellis, April Carcone, Richard Slatcher, Erica Sibinga   +3 more
doaj   +1 more source

UFO Presents! A viral hepatitis prevention and education program for young adult IDUs [PDF]

, 2009
UFO Presents! is a Center for Disease Control and Prevention (CDC)-funded program providing much needed hepatitis education, prevention and care services for youth and young adults with injection risk in San Francisco, CA.

core  

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source