Results 81 to 90 of about 899,725 (268)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

A perspective on the burden of stroke among young adults in Africa

Discover Public Health
Stroke in young adults poses significant public health challenges, with deleterious impacts on individual morbidity and mortality. It significantly affects the productivity and growth of the patients’ families, as well as the communities in which they ...
Tejiri Napoleon, Deborah Akinrinde, Davies Oluwasijibomi Ogheneruona, Chioma Nnedinma Duru, Ucheobi Nonso Christopher, Sodiq Lawal, Emmanuela Ojoagefu Egwu, Chinwekene Okoye, Azubuike Nnagozie, Eleyinmi Oluwafunmilayo, Olawoyin Oluwatosin, Ayodeji Rejoice Oladejo, Olaniyi Michael Oladosu, Ojo Israel Ifeoluwa, Ogungbemi Evelyn Faith, Osunmakinwa Akinoluwa, Elete Shola Tabitha, Ishaq Oyeshina Sanusi   +17 more
doaj   +1 more source

Hemiplegia in Young Adults [PDF]

BMJ, 1947
openaire   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The best PEEP or the optimal PEEP or the piece PEEP of the mechanical power puzzle?

Critical Care, 2022
George Briassoulis, Panagiotis Briassoulis, Stavroula Ilia   +2 more
doaj   +1 more source

Social Isolation, Related Constructs and Problematic School Attendance Problems in Adolescence: A Systematic Review

Children
Background: Problematic school attendance in adolescence is a heterogeneous phenomenon with academic, emotional, and developmental consequences. Although relational factors are increasingly recognised, the literature remains conceptually fragmented, with
Giuseppe Accogli, Giorgia Carlucci, Antonio Trabacca, Maria Gloria Rossetti, Sara Scoditti, Paolo Brambilla, Roberto Sassi, Antonella Delle Fave, Cinzia Bressi, Fabrizia Claudia Guarnieri, Isabella Fanizza, Marcella Bellani   +11 more
doaj   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

The Heat Is On: Climate Change Implications for Pregnant Women with Sickle Cell Disease

Women's Health Reports
Sickle cell disease (SCD), a serious, chronic blood disorder is the most common genetic blood disease in the United States affecting 100,000 people and disproportionately affecting the African American population.
Rachelle Chanmany Pastor, Lisa Roberts, Akshat Jain, Shan Tamares   +3 more
doaj   +1 more source