Results 71 to 80 of about 9,156,647 (313)

Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner.

PLoS ONE, 2019
ObjectiveTo investigate age-associated changes in airway microbiome composition and their relationships with lung function and arterial stiffness among genetically matched young and elderly pairs.MethodsTwenty-four genetically linked family pairs ...
Shuen Yee Lee, Micheál Mac Aogáin, Kai Deng Fam, Kar Ling Chia, Nur A'tikah Binte Mohamed Ali, Margaret M C Yap, Eric P H Yap, Sanjay H Chotirmall, Chin Leong Lim   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Executive function development and stress effects on driving performance : preliminary findings from a young adult sample.

, 2012
This chapter presents a pilot study examining the interactive contributions of executive function development/impairment and psychosocial stress to young adults’ (17-30 years old) driving behaviour in a simulator city ...
Rakotonirainy, Andry, White, Melanie J., Young, Ross McD.   +2 more
core  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Endothelial function in young men with essential hypertension

Российский кардиологический журнал, 2004
The aim of the study was to evaluate the association between markers of endothelial function and arterial hypertension (AH). We measured the plasma level of nitrite and nitrate and flow-mediated vasodilatation of the brachial artery (endothelium ...
G. R. Yanovskaya, V. V. Belov, A. A. Bolotov   +2 more
doaj  

Lung Function in Young Adults and Risk of Cardiovascular Events Over 29 Years: The CARDIA Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Diminished peak lung function in young adulthood is a risk factor for future chronic obstructive pulmonary disease. The association between lung disease and cardiovascular disease later in life is well documented.
Michael J. Cuttica, Laura A. Colangelo, Mark T. Dransfield, Surya P. Bhatt, Jamal S. Rana, David R. Jacobs, Bharat Thyagarajan, Stephen Sidney, Cora E. Lewis, Kiang Liu, Donald Lloyd‐Jones, George Washko, Ravi Kalhan   +12 more
doaj   +1 more source

Lung function of young Aymara highlanders

Annals of Human Biology, 1987
The patterns of development of FVC, FEV and %FEV are examined in 217 male and 195 female youths of Aymara ancestry residing in La Paz, Bolivia (altitude 3600 m). The data provide some evidence of an acceleration in the development of lung function relative to stature in Aymara children, beginning during early adolescence, and also indicate that there ...
L P, Greksa, H, Spielvogel, E, Cáceres, L, Paredes-Fernández   +3 more
openaire   +2 more sources

Executive function and autistic symptomatology in very young children [PDF]

, 2001
The Executive Function hypothesis proposes that the behavioural aspects of autism can be explained by impairment in executive function skills. The term 'executive function' refers to several cognitive skills including inhibitor)'control, generation of ...
Shearer, Heather
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Summary: What have we learned from the Young Lives study in Peru? [PDF]

, 2018
The Young Lives Peru Country Report presents a summary of the main findings that emerge from analysing the Young Lives data from Peru across a longitudinal study following two cohorts of children in various situations from remote rural areas to urban ...
Young Lives, Young Lives, Young
core