Results 91 to 100 of about 4,117,281 (337)

Cardiac autonomic function in healthy young smokers

Toxicology and Industrial Health, 2012
The present study examined the heart rate turbulence (HRT) and heart rate variability (HRV) parameters in healthy young smokers (<40 years) to assess the effects of smoking on cardiac autonomic function. The study included 75 smokers with a history of habitual smoking for at least 1 year (41 males and 34 females; mean age, 29.3 ± 7.3 years) and 30 ...
Alim, Erdem, Suzi Selim, Ayhan, Serkan, Öztürk, Mehmet Fatih, Özlü, Aytekin, Alcelik, Safak, Sahin, Mehmet, Tosun, Fatma Hizal, Erdem, Kenan, Gumustekin, Mehmet, Yazici   +9 more
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Executive Function and young children's Cardinality Principle: the mediating role of the Approximate Number System and the moderating role of age

Frontiers in Psychology
BackgroundExecutive Function and the Approximate Number System are well-established as critical components in developing the Cardinality Principle in young children.
Huanhuan Li, Huijuan Di, Bingyu Duan, Mengzhen Luo, Yifang Wang, Zhenglu Wang   +5 more
doaj   +1 more source

Lung Function in Young Adults and Risk of Cardiovascular Events Over 29 Years: The CARDIA Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Diminished peak lung function in young adulthood is a risk factor for future chronic obstructive pulmonary disease. The association between lung disease and cardiovascular disease later in life is well documented.
Michael J. Cuttica, Laura A. Colangelo, Mark T. Dransfield, Surya P. Bhatt, Jamal S. Rana, David R. Jacobs, Bharat Thyagarajan, Stephen Sidney, Cora E. Lewis, Kiang Liu, Donald Lloyd‐Jones, George Washko, Ravi Kalhan   +12 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Patient-reported mobility function and engagement in young adults with cerebral palsy: A cross-sectional sample

Journal of Children's Orthopaedics, 2018
Purpose To describe self-reported life satisfaction and motor function of young adults with cerebral palsy (CP). Methods A total of 57 young adults with spastic CP classified as levels I (seven), II (25), III (16), IV (nine) by the Gross Motor Function ...
N. Lennon, C. Church, F. Miller
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Theoretical and Observational Agreement on Mass Dependence of Cluster Life Times

, 2004
Observations and N-body simulations both support a simple relation for the disruption time of a cluster as a function of its mass of the form: t_dis = t_4 * (M/10^4 Msun)^gamma.
Bastian, N., Baumgardt, H., Gieles, M., Lamers, H. J. G. L. M.   +3 more
core  

P740 Right ventricular function evaluated by conventional echocardiography and strain imaging: study in young adults born preterm with and without lung disease [PDF]

, 2020
V Bolander, Eva Maret, Per Bergström, Magnus Sköld, Margareta Eriksson   +4 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source