Results 91 to 100 of about 7,512,104 (237)

Listen to us: using the views of WA Aboriginal and Torres Strait Islander children and young people to improve policy and service delivery

, 2015
This report presents the outcomes of a major consultation with Aboriginal children and young people across Western Australia conducted by the Commissioner for Children and Young People WA.
Commissioner for Children and Young People (WA)
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Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

Advanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin, Yu Zhang, Xinyu Qu, Jiayi Liu, Zhongyi Sun, Haibo Liu, Ziyan Chen, Jing Ru, Jingwen Han, Bingqiang Lu, Yan Lu, Yan Wang, Xinyu Zhao, Feng Chen   +13 more
wiley   +1 more source

'Reclaiming place in a tourist town’: Preliminary findings from a social theatre research project run by young people during COVID-19

Annals of Tourism Research Empirical Insights, 2021
Antonia Canosa, Catharine Simmons, Peter J. Cook, Lisa Apostolides, Aiyana Wall, Rory Evington   +5 more
doaj   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

Designing environmental education with young people for young people

This policy paper emphasizes the importance of engaging young people in designing environmental education to promote active and democratic environmental citizenship. It highlights the benefits of co-creation, where youth contribute to curriculum development, making education more relevant and impactful.
Burmeister, Ditte, Juhl Jacobsen, Sif, Åkerman, Maria   +2 more
openaire   +2 more sources

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Patient and Public Involvement (PPI) and Responsible Research and Innovation (RRI) approaches in mental health projects involving young people: a scoping review protocol

Research Involvement and Engagement
Background Rather than being perceived as merely ‘part of the problem’, the perspectives and experiences of young people play a pivotal role in devising effective solutions for mental health challenges.
Josimar Antônio de Alcântara Mendes, Mathijs Lucassen, Alex Adams, Lucy Martin, Christine Aicardi, Rebecca Woodcock, Emma Nielsen, Ellen Townsend, Marina Jirotka   +8 more
doaj   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Children and Young People with Disability Australia (CYDA) education survey 2016

, 2016
Children and Young People with Disability Australia (CYDA) undertakes an annual national survey on the education experiences of students with disability. The 2016 Survey results have been released.
Children and Young People with Disability Australia
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Exploring Responsible Research and Innovation (RRI) in youth mental health: reflections from researchers and young people

Research Involvement and Engagement
Background Responsible Research and Innovation (RRI) promotes inclusive, anticipatory, and reflexive research practices that respond to societal needs. While widely applied in technological fields, its application in youth mental health remains limited ...
Josimar Antônio de Alcântara Mendes, Mathijs Lucassen, Sarah Doherty, Ayan Mahamud, Carolyn Ten Holter, Chris Greenhalgh, Ellen Townsend, Chris Hollis, Marina Jirotka   +8 more
doaj   +1 more source