Results 111 to 120 of about 3,934,978 (257)

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

The composition of MDSC-subpopulations PMN-like, M-like, and e-like MDSC is associated with the severity of infectious mononucleosis in pediatric patients

Frontiers in Immunology
BackgroundPrimary infection with the Epstein-Barr virus (EBV) in early childhood is often asymptomatic, whereas infection with EBV during adolescence or adulthood may lead to infectious mononucleosis (IM).
Lorenz Mihatsch, Karin Bartl, Julia Lange de Luna, Pia Wallraven, Katrin Gerrer, Kirstin Mittelstraß, Josef Mautner, Josef Mautner, Josef Mautner, Elfriede Noessner, Elfriede Noessner, Ulrike Protzer, Ulrike Protzer, Ulrike Protzer, Uta Behrends, Uta Behrends, Uta Behrends, Tanja Bauer, Tanja Bauer, Nina Körber, Nina Körber   +20 more
doaj   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

Ten principles of residential child care

Scottish Journal of Residential Child Care, 2009
The history of residential care for children and young people is quite extensive and features positive stories of resilience and adult-child relationships as well as negative stories of institutional abuse and the abdication of adult responsibility ...
Kiaras Gharabaghi
doaj   +1 more source

Evaluation of Includem’s intensive support services – September 2007 [PDF]

, 2007
In 2005 Includem commissioned a two-year evaluation of its intensive support services provided to young people as part of the Intensive Support and Monitoring Service in Edinburgh, Glasgow, Dundee, East Dunbartonshire, and West Dunbartonshire.
Hill, M., Khan, F.
core   +1 more source

Dual‐Physical‐Field Nanocatalysis: Injectable Hydrogel Enables Piezo‐Photothermal Synergy for Breast Cancer Therapy

Advanced Science, EarlyView.
ABSTRACT Piezocatalytic therapy (PCT) harnesses mechanical energy to generate tumor‐lethal reactive oxygen species (ROS), but its efficacy is limited by rapid electron‐hole recombination and poor intratumoral retention. To overcome these limitations, we engineered heterostructured BiOCl@CuO nanosheets embedded in an injectable, conductive ...
Can Tian, Shihan Xiao, Xuan Chen, Danni Zhang, Zizhen Liu, Jing Wang, Ning Xie, Wei Li   +7 more
wiley   +1 more source

Multiple disruptions: circumstances and experiences of young people living with homelessness and unemployment [PDF]

, 2008
This article is about young people who have experienced both homelessness and unemployment, with their interacting impacts. While ‘young people’ is usually understood to include those beyond childhood and up to 25 years of age, the homelessness services
Batterham, Deb, Cornell, Chelsea, Grace, Marty   +2 more
core  

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Person‐centred care: shifting the power dynamic in the delivery of adolescent and youth‐friendly health services

Journal of the International AIDS Society, 2023
Lynn Phillips, Heleen Soeters, Maximina Jokonya, Allen Kyendikuwa, Luann Hatane   +4 more
doaj   +1 more source

Creative, participatory projects with young people: Reflections over five years

Research for All, 2017
Participatory research is collaborative and democratic, and may be particularly engaging for vulnerable or so-called hard-to-reach groups. In this paper, we describe three creative participatory projects carried out over five years with young people and
doaj   +2 more sources