Results 101 to 110 of about 946,124 (262)

Impact of mental health comorbidity in children and young adults with inflammatory bowel disease: a UK population-based cohort study

BMJ Open
Objective To evaluate the impact of mental health comorbidity in children and young adults with inflammatory bowel disease (IBD).Design Retrospective observational study.Setting Representative population, routinely collected primary care data from the UK
Richard K Russell, Rachel Cooney, Kevin Barrett   +2 more
doaj   +1 more source

An Efficient Biological Codon Recognition Reservoir Computing System Based on Low‐Energy Epitaxial Hf0.52Zr0.48O2 Ferroelectric Memristors

Advanced Science, EarlyView.
This work reports on epitaxially grown Hf0.52Zr0.48O2 ferroelectric memristors with high stability (high durability exceeding 108 cycles and a retention time exceeding 104 s for 16 states) and ultra‐low operating energy consumption (∼121 fJ). A memristor array‐based reservoir computing system is constructed and applied for the first time in the field ...
Ying Liu, Jikang Xu, Yongqing Jia, Wenxuan Wang, Weifeng Zhang, Biao Yang, Xiaobing Yan   +6 more
wiley   +1 more source

The composition of MDSC-subpopulations PMN-like, M-like, and e-like MDSC is associated with the severity of infectious mononucleosis in pediatric patients

Frontiers in Immunology
BackgroundPrimary infection with the Epstein-Barr virus (EBV) in early childhood is often asymptomatic, whereas infection with EBV during adolescence or adulthood may lead to infectious mononucleosis (IM).
Lorenz Mihatsch, Karin Bartl, Julia Lange de Luna, Pia Wallraven, Katrin Gerrer, Kirstin Mittelstraß, Josef Mautner, Josef Mautner, Josef Mautner, Elfriede Noessner, Elfriede Noessner, Ulrike Protzer, Ulrike Protzer, Ulrike Protzer, Uta Behrends, Uta Behrends, Uta Behrends, Tanja Bauer, Tanja Bauer, Nina Körber, Nina Körber   +20 more
doaj   +1 more source

Ultrasound‐Responsive Piezoelectric Fibrous Membrane Promotes Neurological Recovery After TBI by Modulating Microglial Polarization via Restoring Mitochondrial Dynamic Homeostasis

Advanced Science, EarlyView.
We demonstrate a novel therapy for traumatic brain injury TBI using a LIPUS‐responsive Piezoelectric fibrous membrane. It targets microglial mitochondria via in situ electrical signals, restoring homeostasis and reducing oxidative stress to promote an anti‐inflammatory M2 phenotype.
Wei Li, Runzhe Huang, Qingyuan Wu, Pengbo Zhou, Dangli Ren, Jingjing Wang, Hanjie Niu, Zemeng Li, Hongtao Sun, Huiyu Liu   +9 more
wiley   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Person‐centred care: shifting the power dynamic in the delivery of adolescent and youth‐friendly health services

Journal of the International AIDS Society, 2023
Lynn Phillips, Heleen Soeters, Maximina Jokonya, Allen Kyendikuwa, Luann Hatane   +4 more
doaj   +1 more source

Ten principles of residential child care

Scottish Journal of Residential Child Care, 2009
The history of residential care for children and young people is quite extensive and features positive stories of resilience and adult-child relationships as well as negative stories of institutional abuse and the abdication of adult responsibility ...
Kiaras Gharabaghi
doaj   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Young People and Alcohol [PDF]

British Journal of Addiction, 1988
openaire   +2 more sources

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source