Results 101 to 110 of about 3,934,978 (257)

Exploring Responsible Research and Innovation (RRI) in youth mental health: reflections from researchers and young people

open access: yesResearch Involvement and Engagement
Background Responsible Research and Innovation (RRI) promotes inclusive, anticipatory, and reflexive research practices that respond to societal needs. While widely applied in technological fields, its application in youth mental health remains limited ...
Josimar Antônio de Alcântara Mendes   +8 more
doaj   +1 more source

Do young people experiencing the transition from children’s services to adult services understand the process and what their choices are? [PDF]

open access: yes, 2010
This project research examines the understanding that young people who receive services from North Yorkshire Children's Social Care Disabled Children's teams, have of the process of transition to Adult and Community Services.

core  

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

open access: yesAdvanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu   +11 more
wiley   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

open access: yesAdvanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun   +5 more
wiley   +1 more source

Treatment guidelines for rare, early-onset conditions associated with epileptic seizures: a literature review on Rett syndrome and tuberous sclerosis complex

open access: yesOrphanet Journal of Rare Diseases
Background Rett syndrome (RTT) and tuberous sclerosis complex (TSC) are two rare disorders presenting with a range of different epileptic seizures. Seizure management requires careful therapy selection, thereby necessitating development of high-quality ...
S. Amin   +6 more
doaj   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

open access: yesAdvanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas   +6 more
wiley   +1 more source

Youth in Greece [PDF]

open access: yes, 2018
This short report aims to provide a synthesis of Eurofound data and analysis on the situation of young people in Greece. It draws upon existing Eurofound research that examined the issue of young people ‘not in employment, education or training’ (NEET ...
Demetriades, Stavroula
core   +1 more source

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis

open access: yesAdvanced Science, EarlyView.
Considering the great challenge in Glioblastoma multiforme (GBM) treatment, the authors designed and synthesized a multifunctional nanoplatform that effectively induced ferroptosis by synergetically inhibiting intrinsic intrisinc anti‐ferroptosis proteins, GPX4 & DHODH, and realized excellent in vitro and in vivo anti‐GBM effect.
Guodong Ren   +12 more
wiley   +1 more source

Impact of mental health comorbidity in children and young adults with inflammatory bowel disease: a UK population-based cohort study

open access: yesBMJ Open
Objective To evaluate the impact of mental health comorbidity in children and young adults with inflammatory bowel disease (IBD).Design Retrospective observational study.Setting Representative population, routinely collected primary care data from the UK
Richard K Russell   +2 more
doaj   +1 more source

Adolescents and youth with disability: issues and challenges [PDF]

open access: yes, 2004
Globally, almost 180 million young people between the ages of 10-24 live with a physical, sensory, intellectual or mental health disability significant enough to make a difference in their daily lives.
Groce, N.E.
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