Results 121 to 130 of about 1,183,369 (311)

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

open access: yesAdvanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin   +16 more
wiley   +1 more source

Helping unemployed young people to find private sector work

open access: yes, 2014
What challenges do unemployed young people face when trying to get private-sector jobs? With the amount of young people not in education, employment or training (NEET) currently a significant concern to policy-makers, this study looks at the ...
Thompson, Ronald   +3 more
core  

Lost in transition: child to adult cancer services for young people

open access: yes, 2013
Cancer nursing care across the UK has dramatically improved for children and young people with cancer over the past 20 years (Department of Health, 2007).
McInally, Wendy
core   +1 more source

A Novel Approach Based on Acceptor–Donor–Acceptor Type Molecules Enhances the Therapeutic Efficacy and Safety of Photothermal Therapy for Osteosarcoma

open access: yesAdvanced Science, EarlyView.
Jin et al. developed IEICO‐F nanoparticles with enhanced photothermal conversion efficiency via optimized push‐pull effect. Under 808 nm laser, these nanoparticles effectively generated heat to kill osteosarcoma cells and exhibited significant tumor suppression in vivo. Therefore, this novel A‐D‐A type molecule‐based photothermal therapy strategy holds
Zhijian Jin   +9 more
wiley   +1 more source

Young people and political (in)activism: why don't young people vote?

open access: yes, 2006
Continued experimentation with methods to make the process of voting easier signals a growing concern amongst politicians that the public is becoming increasingly disaffected from politics in Britain.
Henn, M, Weinstein, M
core  

Person‐centred care: shifting the power dynamic in the delivery of adolescent and youth‐friendly health services

open access: yesJournal of the International AIDS Society, 2023
Lynn Phillips   +4 more
doaj   +1 more source

Creative, participatory projects with young people: Reflections over five years

open access: yesResearch for All, 2017
Participatory research is collaborative and democratic, and may be particularly engaging for vulnerable or so-called hard-to-reach groups. In this paper, we describe three creative participatory projects carried out over five years with young people and
doaj   +2 more sources

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

open access: yesAdvanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che   +9 more
wiley   +1 more source

Synergistic Probe Combining Lysosome Anchoring and Tumor Defense System Targeting for Precise Tumor Visualization

open access: yesAdvanced Science, EarlyView.
A new generation of high‐precision fluorescent probes based on the lysosomal characteristics in tumor metabolic reprogramming and overexpressed tumor markers. The probe (CN‐D‐GGT) selectively label cancer cells in co‐culture systems and distinguish tumor lesions from inflamedand normal tissues in vivo, enabling precise tumor imaging.
Yang Shen   +6 more
wiley   +1 more source

Bail and remand for young people in Australia: a national research project [PDF]

open access: yes, 2013
Funded and endorsed by the Australasian Juvenile Justice Administrators, this is one of the first national scale research reports into the bail and remand practices for young Australians. A young person can be placed in custody on remand (ie refused bail)
Renshaw, Lauren   +3 more
core  

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