Results 61 to 70 of about 170,841 (292)

The Evolution of Young Star Clusters In Merging Galaxies [PDF]

Symposium - International Astronomical Union, 1999
The formation of young star clusters in merging galaxies is, by now, well established. The new challenge is to use these young clusters as a tool to address some of the outstanding questions. For example, what fraction of these young clusters become globular clusters? Is this enough to explain the difference in the specific globular cluster frequencies
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

JWST Observations of Starbursts: Massive Star Clusters in the Central Starburst of M82

The Astrophysical Journal Letters
We present a near-infrared (NIR) candidate star cluster catalog for the central kiloparsec of M82 based on new JWST NIRCam images. We identify star cluster candidates using the F250M filter, finding 1357 star cluster candidates with stellar masses >10 ^4
Rebecca C. Levy, Alberto D. Bolatto, Divakara Mayya, Bolivia Cuevas-Otahola, Elizabeth Tarantino, Martha L. Boyer, Leindert A. Boogaard, Torsten Böker, Serena A. Cronin, Daniel A. Dale, Keaton Donaghue, Kimberly L. Emig, Deanne B. Fisher, Simon C. O. Glover, Rodrigo Herrera-Camus, María J. Jiménez-Donaire, Ralf S. Klessen, Laura Lenkić, Adam K. Leroy, Ilse De Looze, David S. Meier, Elisabeth A. C. Mills, Juergen Ott, Mónica Relaño, Sylvain Veilleux, Vicente Villanueva, Fabian Walter, Paul P. van der Werf   +27 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A Near-infrared Spectral Library of Very Young Brown Dwarfs and Planetary Mass Objects in the Orion Nebula Cluster

The Astrophysical Journal
Age-benchmark brown dwarf and planetary-mass-object spectroscopy is key to characterizing substellar evolution. In this paper, we present the JHK medium-resolution ( R ∼ 3000) spectra of 25 7–76 M _Jup (spectral types L3.0–M6.0) brown dwarfs and ...
Elena Manjavacas, Mario Gennaro, Sarah Betti, Laurent Pueyo, William O. Balmer, Massimo Robberto   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Emergence of a Lithium Dip in ∼35 Myr “Snake” Open Clusters

The Astrophysical Journal Letters
We report the discovery of a lithium dip (Li dip) in the stellar “Snake” (age = 35 ± 5 Myr), challenging the classical view that Li dips emerge only at ages ≳150 Myr.
Yun-Yi Zhang, Hai-Jun Tian, Jian-Rong Shi, Cheng-Cheng Xie, Xiang-Ming Yang   +4 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Is Earendel a Star Cluster?: Metal-poor Globular Cluster Progenitors at z ∼ 6

The Astrophysical Journal Letters
The strongly lensed z  ∼ 6 Sunrise galaxy offers an incredible opportunity to investigate star formation in the early Universe on parsec or smaller scales.
Massimo Pascale, Liang Dai, Brenda L. Frye, Aliza G. Beverage   +3 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source