Results 71 to 80 of about 6,154 (302)

Massive Star Formation in the Tarantula Nebula

The Astrophysical Journal, 2023
In this work, we present 299 candidate young stellar objects (YSOs) in 30 Doradus discovered using Spitzer and Herschel point-source catalogs, 276 of which are new.
Omnarayani Nayak, Alex Green, Alec S. Hirschauer, Rémy Indebetouw, Margaret Meixner, Tony Wong, Mélanie Chevance, Guido De Marchi, Vianney Lebouteiller, Min-Young Lee, Leslie W. Looney, Suzanne C. Madden, Julia Roman-Duval, Yasuo Fukui, Alvaro Hacar, K. E. Jameson, Venu Kalari, Luuk Oudshoorn, Mónica Rubio, Elena Sabbi   +19 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

7DT Insight: Variability in Young Stellar Objects

The Astronomical Journal
Photometric variability in young stellar objects (YSOs) provides critical insight into the mechanisms of mass accretion, disk evolution, and circumstellar extinction in early stellar evolution.
Mi-Ryang Kim, Jeong-Eun Lee, Myungshin Im, Jinho Lee, Ji Hoon Kim, Seo-Won Chang, Gregory S. H. Paek, Hyeonho Choi, Donggeun Tak, Donghwan Hyun, Won-Hyeong Lee, Hyeyoon Lee, ShinGeon Kim, S. Thomas Megeath   +13 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Illuminating Youth: Decades of Mid-infrared Variability and Color Evolution of Young Stellar Objects

The Astrophysical Journal Supplement Series
The variability of young stellar objects (YSOs) is a crucial tool for understanding the mechanisms driving flux changes. In this study, we present an infrared variability analysis of a large sample of over 20,000 candidate YSOs, using data from the ...
Sharma Neha, Saurabh Sharma
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

DECaPS and SMA Discovery of a Highly Inclined Class I Young Stellar Object with an Outflow: IRAS 08235–4316

The Astronomical Journal
We present images of IRAS 08235–4316 with the Dark Energy Camera Plane Survey (DECaPS; spanning 0.398–1.034 μ m, at ∼1″ resolution) and the Submillimeter Array (SMA; at 1.38 mm (217 GHz) and ∼1 $\mathop{.}\limits^{^{\prime\prime} }$ 9 × 1 $\mathop ...
Joshua Bennett Lovell, Kristina Monsch, Garrett K. Keating, David J. Wilner, Gordian Edenhofer, Mark Gurwell, Ramprasad Rao   +6 more
doaj   +1 more source

Circumstellar Structure Properties of Young Stellar Objects: Envelopes, Bipolar Outflows, and Disks

, 2009
Physical properties of the three main structures in young stellar objects (YSOs), envelopes, bipolar outflows, and circumstellar disks, have been studied using radio interferometers: the Berkeley-Illinois-Maryland Association (BIMA) array and the ...
Kwon, Woojin
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source