Results 121 to 130 of about 2,745,027 (309)

Severe Form of Salih Myopathy Caused by Combination of Two Heterozygous TTN Mutations

open access: yesBalkan Journal of Medical Genetics
Salih myopathy is autosomal recessive hereditary early-onset myopathy with fatal cardiomyopathy. It is a rare and heterogeneous form of congenital titinopathies (TTN).
Milojković M   +4 more
doaj   +1 more source

A systematic survey of type I secretion systems and their substrate proteins in Salmonella

open access: yesVirulence
Type I secretion systems (T1SSs) and the substrates have not been investigated extensively in Salmonella, despite their potential significance. In this research, we screened the comprehensive list of Salmonella T1SSs, observed their evolution and ...
Mingyang Yu   +12 more
doaj   +1 more source

From Page to Stage to Screen and Beyond [PDF]

open access: yes, 2012
A group of Chicago youth media organizations have embarked on an evaluation process with adult program alumni to assess the degree to which hands-on media production and dissemination contributes to developing productive, independent, and engaged ...
Amy Terpstra, Suniya Farooqui
core  

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk

open access: yesAdvanced Science, EarlyView.
This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji   +8 more
wiley   +1 more source

Vulnerable Youth: Background and Policies [PDF]

open access: yes, 2018
[Excerpt] This report first provides an overview of the youth population and the increasing complexity of transitioning to adulthood for all adolescents.
Fernandes-Alcantara, Adrienne L
core   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

open access: yesAdvanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang   +15 more
wiley   +1 more source

Parental Influence in Youth Sport [PDF]

open access: yes, 2019
Youth sport has become one of the most popular outlets for children in today’s society. Youth sport programs and organizations play an important role in the lives of the children that are participating.
Tam, Justine
core   +1 more source

Vitiligo Signature‐Based Drug Screening Identifies Fulvestrant as a Novel Immunotherapy Combination Strategy

open access: yesAdvanced Science, EarlyView.
A vitiligo‐derived gene signature predicts response to immune checkpoint blockade across multiple cancer cohorts, providing a framework for patient stratification. Building on this, Fulvestrant—a clinically approved estrogen receptor degrader—further enhances antitumor immunity by reprogramming tumor‐associated macrophages and promoting CD8⁺ T cell ...
Jie Zhu   +8 more
wiley   +1 more source

Advancing Equity through Effective Youth Engagement in Public Health to Operationalize Racism as a Public Health Crisis: The Flint Public Health Youth Academy Model

open access: yesYouth
Background: The underrepresentation of BIPOC youth in the fields of public health, medicine, and research may be a factor contributing to the disproportionate rates of health disparities in BIPOC communities. In 2004, the Sullivan Commission on Diversity
Kent D. Key   +12 more
doaj   +1 more source

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