Results 121 to 130 of about 2,750,733 (346)

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Climate change, modern slavery, and its impact on health – A youth perspective and global call to action

The Journal of Climate Change and Health
Short Communications - Emerging Issues include timely discussions of topics that may be too preliminary to have a relevant body of literature. They require an unstructured abstract with sections including Introduction, topic sections and Conclusion.
Govind Srihari, Shah Ishaan, Stinchcombe Beth, Benslimane Yasmina, El Amouri Imen, Venté Coha Florencio, Kulesza Victoria, Sanghrajka Aryan, Luchs Aidan, Ho Celine   +9 more
doaj  

Social Services for Youth [PDF]

, 1940

openalex   +1 more source

Outcomes for youth work : coming of age or master’s bidding? [PDF]

, 2012
Providing evidence in youth work is a current and important debate. Modern youth work has, at least to some degree, recognised the need to produce practice information, through its various guises, with limited success as requirements and terminology have
MacKie, Gordon, McGinley, Brian
core  

An Anisotropic Gold‐Palladium Heterostructured Nanosystem for Synergistically Overcoming Radioresistance and Enhancing Melanoma Radioimmunotherapy

Advanced Science, EarlyView.
A multifunctional anisotropic Au‐Pd heterostructured nanosystem is developed that incorporates a plasmonically enhanced Au‐Pd core, with a shell composed of a biodegradable, Mn‐doped targeting peptide. The nanosystem integrates photothermal, radiotherapeutic, and immunomodulatory functions.
Cheng Chen, Yuqi Huang, Wandong Wang, Minghao Chao, Weiguo Sun, Yinghui Kong, Guan Jiang, Yong Gao, Fenglei Gao   +8 more
wiley   +1 more source

Welfare of Youth [PDF]

, 1940
상록 임
openalex   +1 more source

Towards a National Housing Strategy for Homeless Youth [PDF]

, 2013
This policy brief, "Towards a National Housing Strategy for Homeless Youth", is part of a series developed by the Hollywood Homeless Youth Partnership (HHYP) to advance policy and practice recommendations focused on preventing and ending youth ...
Abbe Land, Arlene Schneir, Christianne Ray, Curtis F. Shepard, Heather Carmichael, Mark Supper, Meera Manek, Peggy Edwards, Rachel Romanski, Susan Rabinovitz, Sylvia La Malfa, Tod Lipka   +11 more
core  

Bacteroides Fragilis‐Derived Outer Membrane Vesicles Deliver MiR‐5119 and Alleviate Colitis by Targeting PD‐L1 to Inhibit GSDMD‐Mediated Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Bacteroides fragilis‐derived outer membrane vesicles deliver miR‐5119 and alleviate colitis by targeting PD‐L1 to inhibit GSDMD‐mediated neutrophil extracellular trap formation. Abstract Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system.
Yi Yang, Lanmengxi Yang, Yilin Yang, Haiyi Deng, Shiyu Su, Yinxiao Xia, Jin Su, Yuheng Liu, Junwei Wu, Jing Zhang, Yao Liao, Lifu Wang   +11 more
wiley   +1 more source

Severe Form of Salih Myopathy Caused by Combination of Two Heterozygous TTN Mutations

Balkan Journal of Medical Genetics
Salih myopathy is autosomal recessive hereditary early-onset myopathy with fatal cardiomyopathy. It is a rare and heterogeneous form of congenital titinopathies (TTN).
Milojković M, Jarić M, Stojanović V, Barišić N, Kavečan I   +4 more
doaj   +1 more source

Vulnerable Youth: Background and Policies [PDF]

, 2012
[Excerpt] This report first provides an overview of the youth population and the increasing complexity of transitioning to adulthood for all adolescents.
Fernandes-Alcantara, Adrienne L
core   +2 more sources