Results 221 to 230 of about 3,130,340 (413)

AlphaFold‐Guided Bespoke Gene Editing Enhances Field‐Grown Soybean Oil Contents

open access: yesAdvanced Science, EarlyView.
An AlphaFold‐guided method is developed to functionally optimize soybean sugar transporters and achieve bespoke gene editing of GmSWEET10a/b to improve oil content in an elite soybean cultivar in multi‐year, multi‐site field trials. The combination of AI‐guided protein design and gene editing may unlock a huge potential to improve the genetic trait de ...
Jie Wang   +22 more
wiley   +1 more source

Latent class analysis of actigraphy within the depression early warning (DEW) longitudinal clinical youth cohort

open access: yesChild and Adolescent Psychiatry and Mental Health
Background Wearable-generated data yield objective information on physical activity and sleep variables, which, are in turn, related to the phenomenology of depression.
Lydia Sequeira   +7 more
doaj   +1 more source

Rural Youth: Activities, Interests, and Problems.

open access: green, 1936
Craig A. Anderson   +2 more
openalex   +2 more sources

Dual Role of CRABP2 in Colorectal Cancer: Oncogenesis via Nuclear RB1 and Cytoplasmic AFG3L2/SLC25A39 Axis, While Limiting Liver Metastasis through Cytoplasmic AFG3L2/PINK1/Parkin‐Mediated Mitophagy

open access: yesAdvanced Science, EarlyView.
CRABP2 plays a dual role in colorectal cancer: it promotes proliferation and suppresses apoptosis through the nuclear CRABP2/RB1 axis and the cytoplasmic AFG3L2/SLC25A39 axis. Meanwhile, it inhibits colorectal liver metastasis via AFG3L2/PINK1/Parkin‐mediated mitophagy.
Chuanxin Tian   +14 more
wiley   +1 more source

Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury

open access: yesAdvanced Science, EarlyView.
Dipyridamole acts as a clinically used compound to suppress ferroptosis. Dipyridamole down‐regulates the expression of RNF126, which is an E3 ligase to ubiquitinate SLC7A11 for proteasome degradation. The deficiency of SLC7A11 largely abolishes the protective role of dipyridamole both in vitro and in vivo.
Xiao Zhuang   +22 more
wiley   +1 more source

Family Day Care in Germany – the gap between vision and reality

open access: yesJournal of Early Childhood Education Research, 2015
In Germany, family day care has dominated for a long time as a more or less informal provision of childcare. With massive legal changes in the system of Early Childhood Education and Care (ECEC) since 2006, family day care became a part of the formal ...
Gabriel Schoyerer, Nina Weimann-Sandig
doaj  

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