Results 91 to 100 of about 123,043 (297)

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Teachers’ Social Representations in Relation to EJA: affectivity and teacher training

Educação & Realidade, 2017
The aim of this article is to present Youth and Adult Education - EJA teachers’ social representations, concerning their teacher training and affectivity in the teaching-learning process.
Poliana da Silva Almeida Santos Camargo
doaj  

CONTRIBUIÇÕES GRAMSCIANAS PARA UMA EDUCAÇÃO UNITÁRIA NA EDUCAÇÃO DE JOVENS E ADULTOS

Cadernos de Pesquisa, 2015
Este texto objetiva elencar aproximações e distanciamentos entre a Escola Unitária idealizada por Gramscie a Educação de Jovens e Adultos (EJA). Esta investigação caracteriza-se como pesquisa bibliográfica, em quese realizou o cruzamento de fontes ...
Wesley Silva Mauerverck, Cátia Regina Assis Almeida Leal   +1 more
doaj   +1 more source

EDUCATION OF YOUTH AND ADULTS AND SOLIDARITY ECONOMY

, 2016
A primeira experiência de formação continuada de profissionais da educação, em escala nacional, iniciou-se nos anos 1950. A Campanha de formação não durou duas décadas. Com sua extinção, a formação continuada restringiu-se a atividades descontínuas, geograficamente pulverizadas. Em 2011, o governo federal criou o sistema nacional de formação continuada,
Gomes, Delarim Martins, Silva, Maria Urbana da   +1 more
openaire   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Educação ainda que tardia: a exclusão da escola e a reinserção de adultos das camadas populares em um programa de EJA

Revista Brasileira de Educação, 2003
This research sought to comprehend the impacts which the experience of premature exclusion from school and that of second chance schooling have on the life of working class adults, privileging the narrative of former students of a programme of ...
Geovânia Lúcia dos Santos
doaj  

Unveiling Mechanisms of SEI Formation and Sodium Loss in Sodium Batteries via Interface Reactor Sampling

Advanced Science, EarlyView.
An “Interface Reactor” strategy boosts simulation stability by 2–3 orders of magnitude, enabling stable 100 ns molecular dynamics of electrode‐electrolyte interfaces. Distinct SEI formation mechanisms are revealed: mixed co‐formation in carbonates versus surface‐energy‐controlled NaF crystallization in ethers. Metadynamics simulations further elucidate
Zhoulin Liu, Ziliang Wang, Zherui Chen, Jianchun Sha, Fengzijun Pan, Pingyang Zhang, Yinghe Zhang   +6 more
wiley   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Longitudinal surveys of Australian youth annual report 2013 [PDF]

, 2014
The purpose of LSAY LSAY is designed to examine major transition points in young people’s lives, including completing school and transitioning to work or further training and education, as well as other aspects of their lives.
Department of Education and Training (Australia), National Centre for Vocational Education Research   +1 more
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