Results 101 to 110 of about 123,043 (297)

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Becoming Activist: Collaboratively Documenting the Critical Literacy Praxis of Urban Youth Organizers [PDF]

, 2014
This research study explores the critical literacy praxis of five urban youth organizers. As a literacy study, this research answers two central questions: How do urban youth organizers engage in critical literacy praxis as they become activists?
Bishop, Elizabeth M
core  

Youth as Knowledge Producers: Experiencing Home-Based Sexuality Education in LGBTQ+ Families

Youth
Relationship and sexuality education research has largely centred on adult perspectives, particularly in exploring home-based sexuality education. This study shifts the lens to youth voices by examining how adolescents from LGBTQ+ families in South ...
Jane Rossouw
doaj   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

The impact of the fathers’ job loss during the 1980s recession on their child’s educational attainment and later labour market outcomes [PDF]

, 2012
The research on intergenerational correlations in outcomes is increasingly moving from measurement into assessment of causal transmission mechanisms. This paper analyses the causal impact of fathers’ job loss on their children’s educational attainment ...
Nasim, Bilal, Gregg, Paul, Macmillan, Lindsey   +2 more
core  

Hidden among the Under-represented: Foster Youth Access and Persistence in Ontario Post-secondary Education [PDF]

, 2019
The pathway to and through post-secondary education begins in early life. Individuals require academic preparation, to be made aware of post-secondary options, become engaged in the processes and procedures necessary for enrollment, transition to their ...
Ferguson, Renee Justine
core   +2 more sources

Make a Move+: A Cluster-Randomized Controlled Trial of a Program Targeting Psychosexual Health and Sexual and Dating Violence for Dutch Male Youth with Mild Intellectual Disabilities

Youth
While male youths with mild intellectual disabilities (MIDs) display similar sexual development as their peers without MIDs, they experience higher rates of sexual and dating violence (SDV) and sexual risk behavior.
Mirthe C. Verbeek, Daphne van de Bongardt, Maartje P. C. M. Luijk, Elizabeth Miller, Eric A. W. Slob, Joyce Weeland   +5 more
doaj   +1 more source

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, EarlyView.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

Report of the Royal Commission on Education and Youth summary.

, 1968
Province of Newfoundland and Labrador Report of The Royal Commission on Education and YouthWhy is education so important? -- Some documentation. Drop-out rate -- Pupil achievement -- Other tests -- Public examinations -- Equality a myth -- Criticisms of ...
Wilson, Isabel
core