Results 211 to 220 of about 267,171 (315)

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai   +12 more
wiley   +1 more source

EGaIn‐Activated Bioinspired Silk Micro/Nanofibril Eutectogels Breaking the Strength–Conductivity Trade‐Off for High‐Performance Wearable Bioelectronics

open access: yesAdvanced Science, EarlyView.
Inspired by the extracellular matrix, eutectogels are prepared by in situ deconstruction of silk fibroin into micro/nanofibrils and EGaIn‐induced polymerization. The multiscale fibril network with dynamic crosslinking achieves high strength (1.25 MPa), toughness (23.09 MJ m−3), and conductivity (1.51 S m−1), outperforming previous natural polymer ...
Haiwei Yang   +4 more
wiley   +1 more source

Phase‐Engineered Non‐Degenerate Sliding Ferroelectricity Enables Tunable Photovoltaics in Monolayer Janus In2S2Se

open access: yesAdvanced Science, EarlyView.
The meticulously phase‐engineered non‐degenerate sliding ferroelectricities in monolayer In2S2Se, along with their tunable impacts on photovoltaic performances, introduce innovative perspectives for the future design and optimization of 2D advanced photovoltaic devices.
Yixuan Li   +9 more
wiley   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

open access: yesAdvanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu   +12 more
wiley   +1 more source

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