Results 81 to 90 of about 1,801,862 (314)

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

open access: yesAdvanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao   +7 more
wiley   +1 more source

The Art & Science of Creating Effective Youth Programs [PDF]

open access: yes, 2017
"The Art & Science of Creating Effective Youth Programs" utilizes findings from a national collective impact study conducted by Algorhythm through their Youth Development Impact Learning System (YDiLS), which surveyed 27 organizations, 80 programs and ...
Kim Sabo-Flores, Peter York
core  

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

open access: yesAdvanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang   +14 more
wiley   +1 more source

New on the Shelf: Teens in the Library [PDF]

open access: yes, 2004
Details a number of positive effects of the Wallace Foundation's Public Libraries as Partners in Youth Development initiative, and explores what is necessary to implement and sustain high-quality youth programs in public ...
Carol Horton   +2 more
core  

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

open access: yesAdvanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi   +12 more
wiley   +1 more source

The Challenge of Creating a Developmental Approach to Youth Employment [PDF]

open access: yes, 2003
Analyzes the effectiveness of federally funded youth employment and training programs. Examines various approaches to youth employment and development, and the effect that policy changes and reduced resources have had on support for the ...
Alan Zuckerman
core  

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

open access: yesAdvanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang   +11 more
wiley   +1 more source

FedLag - A New Paradigm for Enhancing Global Model Resilience [PDF]

open access: yesITM Web of Conferences
Federated Learning (FL) enables decentralized model training on edge devices without sharing raw data, ensuring data privacy. However, most existing aggregation methods such as FedAvg, FedProx, FedNova, AFL, and SCAFFOLD rely on simple averaging or ...
Manikandan Srimathi, Kanna B Rajesh
doaj   +1 more source

Bridging Community, Research, and Action: An Emerging Center on Latino Youth Development (FOCUS) [PDF]

open access: yes, 2006
This NCCD FOCUS is an update on the community conversations held across California with Latino community stakeholders on the status of Latino youth and the creation of a Center on Latino Youth ...
Angela Gallegos-Castillo, Vanessa Patino
core  

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy