Results 251 to 260 of about 2,164,210 (341)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

open access: yesAdvanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang   +13 more
wiley   +1 more source

Correction: BET inhibitor-based combinations targeting novel dependencies in MECOM-rearranged (r) AML. [PDF]

open access: yesLeukemia
Birdwell CE   +17 more
europepmc   +1 more source

DNA Nanoarray for Multiplexed RNA Detection With Single‐Molecule Readout

open access: yesAdvanced Science, EarlyView.
A carrier‐based DNA nanoarray integrates programmable nucleic acid hybridization with solid‐state nanopore readout for direct RNA detection at single‐molecule resolution. A ternary encoding system enables 27 carriers with 81 addressable sensing sites, allowing the simultaneous identification of targets spanning a wide size range, from short microRNAs ...
Yunxuan Li   +12 more
wiley   +1 more source

Microstructure Optimization of Na3SbS4/Na3Zr2Si2PO12 Composite Solid Electrolytes for Improving Cycling Stability in All‐Solid‐State Sodium Batteries

open access: yesAdvanced Science, EarlyView.
This research demonstrates that incorporating 10 wt.% NASICON‐type Na3Zr2Si2PO12 into Na3SbS4 sulfide electrolytes mitigates interfacial instability and structural defects. The resulting composite enhances ionic conductivity to 3.97 * 10−4 S cm−1 and reduces activation energy.
Celastin Bebina Thairiyarayar   +4 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

open access: yesAdvanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu   +10 more
wiley   +1 more source

Complex peopling history and expansion events inferred from large-scale modern and ancient Y chromosome sequences. [PDF]

open access: yesSci Adv
He G   +12 more
europepmc   +1 more source

CMOS‐Integrated Synaptic Photoreceptor Chip Inspired by Insect Visual Processing

open access: yesAdvanced Science, EarlyView.
CMOS‐integrated Si QDs/ReS2 synaptic photoreceptor array mimics the parallel processing and wavelength‐selective strategy of insect vision. By combining intrinsic ultraviolet‐violet sensitivity with synaptic plasticity, the chip enables frontend sensory redundancy reduction without external filters, offering a scalable pathway toward lowpower ...
Jian Chai   +25 more
wiley   +1 more source

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