Results 51 to 60 of about 3,851,324 (263)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Life, 2020 Essential oil components of Nelumbo nucifera flowers from cultivated and wild lotus samples were analyzed and compared using three different extraction techniques, i.e., headspace extraction (HE), steam distillation (SD) and solvent extraction (SE ...
Chun-Yun Zhang, Mingquan Guo
semanticscholar +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Exact polynomial solutions of second order differential equations and their applications
, 2011 We find all polynomials $Z(z)$ such that the differential equation $${X(z)\frac{d^2}{dz^2}+Y(z)\frac{d}{dz}+Z(z)}S(z)=0,$$ where $X(z), Y(z), Z(z)$ are polynomials of degree at most 4, 3, 2 respectively, has polynomial solutions $S(z)=\prod_{i=1}^n(z-z_i)
Zhang, Yao-Zhong
core +1 more source
IEEE AccessNanopore sequencers generate raw electrical signals representing the contents of a biological sequence molecule passing through the nanopore. These signals can be analyzed directly, avoiding basecalling entirely.
Joel Lindegger +5 more
doaj +1 more source
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2023 Time series of optical imagery allow one to derive land surface phenology metrics. These metrics are only complete with a statement about their uncertainty. A source of uncertainty is the radiometry of the sensor.
Lukas Valentin Graf +4 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Geometric Properties of Partial Sums of Univalent Functions [PDF]
, 2012 The $n$th partial sum of an analytic function $f(z)=z+\sum_{k=2}^\infty a_k z^k$ is the polynomial $f_n(z):=z+\sum_{k=2}^n a_k z^k$. A survey of the univalence and other geometric properties of the $n$th partial sum of univalent functions as well as ...
Ravichandran, V.
core