Results 61 to 70 of about 3,260 (145)
Zanubrutinib Treatment of Central Nervous System Posttransplant Lymphoproliferative Disorder After Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report
Frontiers in Oncology, 2021 Posttransplant lymphoproliferative disorder (PTLD) is a rare complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with poor prognosis.Ting-Ting Yang, Ting-Ting Yang, Ting-Ting Yang, Wei-Hao Chen, Wei-Hao Chen, Wei-Hao Chen, Yan-Min Zhao, Yan-Min Zhao, Yan-Min Zhao, Hua-Rui Fu, Hua-Rui Fu, Hua-Rui Fu, He Huang, He Huang, He Huang, Ji-Min Shi, Ji-Min Shi, Ji-Min Shi +17 moredoaj +1 more sourceExtranodal Marginal Zone Lymphoma: Integrating Etiology, Microenvironment, and Genetics Into Clinical Decision‐Making
European Journal of Haematology, Volume 117, Issue 4, Page 849-863, October 2026.ABSTRACT
Extranodal marginal zone lymphoma (EMZL) represents a unique paradigm among indolent B‐cell neoplasms, in which lymphomagenesis is frequently driven by chronic antigenic stimulation within tissue‐specific microenvironments. Persistent infectious or autoimmune triggers promote the development of ectopic lymphoid tissue and sustain B‐cell ...Mamdouh Skafi, Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Marco Fiorillo, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile +15 morewiley +1 more sourceEfficacy and Safety Profile of a Rituximab, Methotrexate, and Thiotepa‐Based Regimen in Newly Diagnosed Primary CNS Lymphoma
International Journal of Cancer, Volume 159, Issue 6, Page 1499-1509, 15 September 2026.Primary central nervous system diffuse large B‐cell lymphoma (PCNS‐DLBCL) lacks an optimal first‐line induction strategy, particularly for older patients and those ineligible for intensive consolidation. In this retrospective cohort of 36 newly diagnosed patients, the rituximab + methotrexate + thiotepa (RMT) regimen as first‐line induction achieved ...Haotian Wang, Jia Li, Luming Cao, Ying Zhang, Xin Wan, Xingtong Wang, Yangzhi Zhao, Zhaoxia Li, Chengqian Chen, Yang Song, Ou Bai +10 morewiley +1 more sourceZanubrutinib versus acalabrutinib indirect treatment comparison in relapsed or refractory mantle cell lymphoma [PDF]
Zanubrutinib and acalabrutinib have demonstrated efficacy in separate single-arm clinical trials in patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL).Shah, B., Ren, S., Srivastava, T., Yang, K., Xu, S., Saba, N.S., Gautam, R., Williams, R., Challagulla, S., Tam, C.S. +9 morecore +1 more sourceIbrutinib, but not zanubrutinib, induces platelet receptor shedding of GPIb-IX-V complex and integrin αIIbβ3 in mice and humans
Blood Advances, 2019 : The Bruton's tyrosine kinase (Btk) inhibitor ibrutinib has proven to be efficacious in the treatment of B-cell chronic lymphocytic leukemia (B-CLL) and related diseases.Gasim Dobie, Fahd A. Kuriri, Musab M.A. Omar, Fehaid Alanazi, Ali M. Gazwani, Chloe P.S. Tang, Daniel Man-yuen Sze, Sasanka M. Handunnetti, Constantine Tam, Denise E. Jackson +9 moredoaj +1 more sourceA functional prognostic model predicts progression‐free survival in patients with relapsed chronic lymphocytic leukemia treated with ibrutinib + venetoclax
HemaSphere, Volume 10, Issue 9, September 2026.Abstract
Targeted therapies have improved outcomes for patients with chronic lymphocytic leukemia (CLL); yet, not all achieve durable responses. Existing prognostic models, developed for chemoimmunotherapy, have limited predictive value for newer targeted combinations.Johanne U. Hermansen, Weikaixin Kong, Andrea M. Brodersen, Yanping Yin, Aleksandra Urban, Idun D. Rein, Liye He, Rudi Agius, Rebecca S. Teglgaard, Juho Rousu, Christian Brieghel, Sabina Kersting, Mark‐David Levin, Hoa T. T. Tran, Mattias Mattsson, Juha Ranti, Gerrit‐Jan Veldhuis, Caspar da Cunha‐Bang, Rogier Mous, Julie Dubois, Arnon P. Kater, Jorrit M. Enserink, Carsten U. Niemann, Tero Aittokallio, Sigrid S. Skånland +24 morewiley +1 more sourceIndirect Comparisons of the Efficacy and Safety of Zanubrutinib versus Venetoclax plus Obinutuzumab in Treatment-Naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Oncology and TherapyIntroduction Compared with chemoimmunotherapy, both zanubrutinib monotherapy and venetoclax plus obinutuzumab prolong progression-free survival (PFS) in patients with chronic lymphocytic leukemia (CLL). Matching-adjusted indirect comparison (MAIC) can be Talha Munir, Nicolás Martinez-Calle, Sheng Xu, Keri Yang, Xiaoyun Ge, Ayad K. Ali, Leyla Mohseninejad, Balázs Dobi, Pal Rakonczai, Han Ma, Rhys Williams, Wassim Aldairy, Nicole Lamanna +12 moredoaj +1 more sourceReal‐World Determinants of Treatment Selection in Frontline Chronic Lymphocytic Leukemia: The FIRST‐CLL Study
Hematological Oncology, Volume 44, Issue 5, September 2026.ABSTRACT
Multiple targeted agents are available for first‐line treatment of chronic lymphocytic leukemia (CLL), yet the absence of mature head‐to‐head comparisons makes treatment selection challenging. The prospective, multicenter FIRST‐CLL study evaluated real‐world treatment allocation, and the contribution of biological, clinical, logistical and ...Francesca Perutelli, Matteo Arata, Raffaella Pasquale, Sara Pepe, Maura Nicolosi, Marina Deodato, Ilaria Piras, Erika Fioribello, Alessandro Bosi, Riccardo Moia, Andrea Ferrario, Michela Schirru, Elia Boccellato, Martina Bullo, Daniela Gottardi, Myriam Foglietta, Andrea Galitzia, Marta Coscia, Gianluca Gaidano, Michele Merli, Chiara Salvetti, Roberta Murru, Anna Maria Frustaci, Roberto Freilone, Jacopo Olivieri, Francesca Romana Mauro, Benedetto Bruno, Candida Vitale +27 morewiley +1 more sourceZanubrutinib is well tolerated and effective in patients with CLL/SLL intolerant of ibrutinib/acalabrutinib: updated results
Blood Advances: Bruton tyrosine kinase (BTK) inhibitors such as ibrutinib (ibr) revolutionized chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) treatment, although treatment-related toxicities limit the use of some BTK inhibitors.Mazyar Shadman, John M. Burke, Jennifer Cultrera, Habte A. Yimer, Syed F. Zafar, Jamal Misleh, Subramanya S. Rao, Charles M. Farber, Aileen Cohen, Hui Yao, Adam Idoine, Qi An, Ian W. Flinn, Jeff P. Sharman +13 moredoaj +1 more source