Results 121 to 130 of about 104,470 (312)

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

open access: yesAdvanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong   +6 more
wiley   +1 more source

Wisdom Peak. Robert Moore Becomes Zen Master Ji Bong

open access: yes, 1997
Providence Zen Center, April 5, 1997. Robert Moore - professor of music, guiding teacher of Dharma Zen Center in Los Angeles, student of jazz, and teacher of t'ai chi and chi kung - received a ceremonial whisk, wooden bowls and an embroidered gold kasa ...
Ji Bong Hae Um, Zen Master (Moore, Robert S.)
core  

KamLAND-Zen

open access: yes, 2018
KamLAND-Zen searches for neutrinoless double beta (0nbb) decay with Xe-136 loaded liquid scintillator. Results from "KamLAND-Zen 400" are based upon data collected from 2011 to 2015 and we obtained the most stringent lower limit for 0nbb decay half-life ...
Gando, Azusa, Gando, Azusa (5370272)
core   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen   +7 more
wiley   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng   +5 more
wiley   +1 more source

Zen and Words: Sacred Texts in the Zen Tradition

open access: yesDarulfunun Ilahiyat
The Zen tradition defines itself as a teaching and truth that is beyond words and language. According to Zen masters, Zen truth cannot be explained in words or language, nor can it be understood through the dualistic thought structure.
Merve Susuz Aygül
doaj   +1 more source

ZEN-definisjonen – en veileder for ZEN-pilotområder. Versjon 4.0. Norsk [PDF]

open access: yes
Denne fjerde og siste utgaven (versjon 4.0) av ZEN-definisjonsveilederen bygger på v.1.0, v.2.0 og v.3.0 av ZEN-definisjonsveilederne, samt en rekke andre ZEN-definisjonsrapporter.
Lien, Synne Krekling   +6 more
core  

Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers

open access: yesAdvanced Science, EarlyView.
Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang   +5 more
wiley   +1 more source

Prosessveileder for ZEN [PDF]

open access: yes
Det overordnede målet med denne rapporten er å veilede partene i ZEN (som for eksempel ledende organisasjon(er), prosjekteiere, utviklere, prosjektleveranseteam osv.) som vil ha mandat til å gjennomføre prosjekter innenfor et nullutslippsområde (ZEN) og ...
Rokseth, Lillian Sve   +2 more
core  

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin   +11 more
wiley   +1 more source

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