Results 91 to 100 of about 80,890 (284)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Zero-sum problems and coverings by proper cosets
, 2003 Let G be a finite Abelian group and D(G) its Davenport constant, which is defined as the maximal length of a minimal zero-sum sequence in G. We show that various problems on zero-sum sequences in G may be interpreted as certain covering problems.
Gao, Weidong, Geroldinger, Alfred
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye +11 more
wiley +1 more source
Subsequence Sums of Zero-sum free Sequences II
Ars Comb., 2009 Let $G$ be a finite abelian group, and let $S$ be a sequence over $G$. Let $f(S)$ denote the number of elements in $G$ which can be expressed as the sum over a nonempty subsequence of $S$. In this paper, we determine all the sequences $S$ that contains no zero-sum subsequences and $f(S)\leq 2|S|-1$.
openaire +2 more sources
Topological methods in zero-sum Ramsey theory
, 2023 A cornerstone result of Erd\H os, Ginzburg, and Ziv (EGZ) states that any sequence of $2n-1$ elements in $\mathbb{Z}/n$ contains a zero-sum subsequence of length $n$.
Wellner, Zoe +7 more
core
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
A Multistrategy Improved Archimedes Optimization Algorithm for Solving Engineering Problems
Journal of MathematicsGiven the shortcomings of the Archimedes optimization algorithm (AOA), the traditional AOA exhibits the following limitations: the initialization phase employs a uniform 0-1 random number distribution to generate sequences, resulting in limited diversity
Xiaoping Xu +5 more
doaj +1 more source
Ramsey theory, Discrepancy Theory, Zero-Sums and Symmetric Functions
, 2020 The underlying philosophy of Ramsey Theory is that total disorder is impossible, and the underlying philosophy of Discrepancy Theory is that a totally equal distribution is impossible.
Bialostocki, Arie
core
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source