Results 71 to 80 of about 80,890 (284)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Journal of Translational Medicine, 2012 Background High systemic estrogen levels contribute to breast cancer risk for postmenopausal women, whereas low levels contribute to osteoporosis risk. Except for obesity, determinants of non-ovarian systemic estrogen levels are undefined.
Flores Roberto +8 more
doaj +1 more source
On Sequences with Zero Autocorrelation and Orthogonal Designs
, 2001 We propose some methods for multiplying the length and type of sequences with elements on a set of commuting variables which have zero non-periodic autocorrelation function.
S. Georgiou +5 more
core +1 more source
A new additive function and the Smarandache divisor product sequences [PDF]
, 2009 The main purpose of this paper is using the elementary method and the prime distribution theory to study the mean value properties of G(n) in Smarandache divisor product sequences fpd(n)g and fqd(n)g, and give two sharper asymptotic formulae for ...
Weili, Yao +3 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Avoiding Zero-Sum Sequences of Prescribed Length Over the Integers
Integers, 2016 13 pages. Added a new reference, corrected typos in the proof of Lemma 13, and added more details to the proof of Theorem ...
C. Augspurger +4 more
openaire +4 more sources
On the index of length four minimal zero-sum sequences [PDF]
Colloquium Mathematicum, 2014 Let $G$ be a finite cyclic group. Every sequence $S$ over $G$ can be written in the form $S=(n_1g)\cdot\ldots\cdot(n_lg)$ where $g\in G$ and $n_1, \ldots, n_l\in[1, \ord(g)]$, and the index $\ind(S)$ of $S$ is defined to be the minimum of $(n_1+\cdots+n_l)/\ord(g)$ over all possible $g\in G$ such that $\langle g \rangle =G$.
Shen, Caixia, Xia, Li-meng, Li, Yuanlin
openaire +2 more sources
Comparing system of sets of lengths over finite abelian groups
, 2020 For $(G,+,0) $ a finite abelian group and $S= g_1 \dots g_k $ a sequence over $G$, we denote by $\sigma(S)$ the sum of all terms of $S$. We call $|S|=k$ the length of the sequence. If the sum of $S$ is $0$, we say that $S$ is a zero-sum sequence.
Schmid, Wolfgang
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source